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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A shear gradient-activated microfluidic device for automated monitoring of whole blood haemostasis and platelet function
|
|---|---|
| Published in |
Nature Communications, January 2016
|
| DOI | 10.1038/ncomms10176 |
| Pubmed ID | |
| Authors |
Abhishek Jain, Amanda Graveline, Anna Waterhouse, Andyna Vernet, Robert Flaumenhaft, Donald E. Ingber |
| Abstract |
Accurate assessment of blood haemostasis is essential for the management of patients who use extracorporeal devices, receive anticoagulation therapy or experience coagulopathies. However, current monitoring devices do not measure effects of haemodynamic forces that contribute significantly to platelet function and thrombus formation. Here we describe a microfluidic device that mimics a network of stenosed arteriolar vessels, permitting evaluation of blood clotting within small sample volumes under pathophysiological flow. By applying a clotting time analysis based on a phenomenological mathematical model of thrombus formation, coagulation and platelet function can be accurately measured in vitro in patient blood samples. When the device is integrated into an extracorporeal circuit in pig endotoxemia or heparin therapy models, it produces real-time readouts of alterations in coagulation ex vivo that are more reliable than standard clotting assays. Thus, this disposable device may be useful for personalized diagnostics and for real-time surveillance of antithrombotic therapy in clinic. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 288 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | <1% |
| Denmark | 2 | <1% |
| Netherlands | 1 | <1% |
| United Kingdom | 1 | <1% |
| Taiwan | 1 | <1% |
| Japan | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Unknown | 279 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 79 | 27% |
| Researcher | 44 | 15% |
| Student > Master | 35 | 12% |
| Student > Bachelor | 30 | 10% |
| Student > Doctoral Student | 13 | 5% |
| Other | 35 | 12% |
| Unknown | 52 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 87 | 30% |
| Agricultural and Biological Sciences | 35 | 12% |
| Medicine and Dentistry | 26 | 9% |
| Biochemistry, Genetics and Molecular Biology | 17 | 6% |
| Materials Science | 13 | 5% |
| Other | 43 | 15% |
| Unknown | 67 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 73. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 May 2019.
All research outputs
#493,059
of 22,837,982 outputs
Outputs from Nature Communications
#8,673
of 47,024 outputs
Outputs of similar age
#9,665
of 393,663 outputs
Outputs of similar age from Nature Communications
#158
of 753 outputs
Altmetric has tracked 22,837,982 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 47,024 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.7. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 393,663 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 753 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.