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PGRNseq

Overview of attention for article published in Pharmacogenetics and Genomics, April 2016
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (61st percentile)
  • Good Attention Score compared to outputs of the same age and source (66th percentile)

Mentioned by

twitter
6 tweeters

Citations

dimensions_citation
48 Dimensions

Readers on

mendeley
36 Mendeley
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Title
PGRNseq
Published in
Pharmacogenetics and Genomics, April 2016
DOI 10.1097/fpc.0000000000000202
Pubmed ID
Authors

Adam S. Gordon, Robert S. Fulton, Xiang Qin, Elaine R. Mardis, Deborah A. Nickerson, Steve Scherer

Abstract

Although the costs associated with whole-genome and whole-exome next-generation sequencing continue to decline, they remain prohibitively expensive for large-scale studies of genetic variation. As an alternative, custom-target sequencing has become a common methodology on the basis of its favorable balance between cost, throughput, and deep coverage. We have developed PGRNseq, a custom-capture panel of 84 genes with associations to pharmacogenetic phenotypes, as a tool to explore the relationship between drug response and genetic variation, both common and rare. We utilized a set of 32 diverse HapMap trios and two clinical cohorts to assess platform performance, accuracy, and ability to discover novel variation. We found that PGRNseq generates ultra-deep coverage data (mean=496×) that are over 99.8% concordant with orthogonal datasets. In addition, in our testing sets, PGRNseq identified many novel, rare variants of interest, underscoring its value in both research and clinical settings. PGRNseq is an ideal platform for carrying out sequencing-based analyses of pharmacogenetic variation in large cohorts. In addition, the high accuracy associated with genotypes from PGRNseq highlight its utility as a clinical test.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 3%
Brazil 1 3%
Unknown 34 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 28%
Student > Doctoral Student 3 8%
Student > Ph. D. Student 3 8%
Student > Master 3 8%
Other 2 6%
Other 5 14%
Unknown 10 28%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 11 31%
Agricultural and Biological Sciences 5 14%
Medicine and Dentistry 3 8%
Pharmacology, Toxicology and Pharmaceutical Science 2 6%
Engineering 2 6%
Other 3 8%
Unknown 10 28%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2016.
All research outputs
#8,092,947
of 15,350,461 outputs
Outputs from Pharmacogenetics and Genomics
#302
of 824 outputs
Outputs of similar age
#137,279
of 369,397 outputs
Outputs of similar age from Pharmacogenetics and Genomics
#6
of 24 outputs
Altmetric has tracked 15,350,461 research outputs across all sources so far. This one is in the 46th percentile – i.e., 46% of other outputs scored the same or lower than it.
So far Altmetric has tracked 824 research outputs from this source. They receive a mean Attention Score of 2.7. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 369,397 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.