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Cryptotanshinone inhibits TNF-α-induced early atherogenic events in vitro

Overview of attention for article published in The Journal of Physiological Sciences, January 2016
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Title
Cryptotanshinone inhibits TNF-α-induced early atherogenic events in vitro
Published in
The Journal of Physiological Sciences, January 2016
DOI 10.1007/s12576-015-0410-7
Pubmed ID
Authors

Zuraini Ahmad, Chin Theng Ng, Lai Yen Fong, Nurul Ain Abu Bakar, Nor Hayuti Mohd Hussain, Kok Pian Ang, Gwendoline Cheng Lian Ee, Muhammad Nazrul Hakim

Abstract

Endothelial dysfunction has been implicated in the pathogenesis of atherosclerosis. Salvia miltiorrhiza (danshen) is a traditional Chinese medicine that has been effectively used to treat cardiovascular disease. Cryptotanshinone (CTS), a major lipophilic compound isolated from S. miltiorrhiza, has been reported to possess cardioprotective effects. However, the anti-atherogenic effects of CTS, particularly on tumor necrosis factor-α (TNF-α)-induced endothelial cell activation, are still unclear. This study aimed to determine the effect of CTS on TNF-α-induced increased endothelial permeability, monocyte adhesion, soluble intercellular adhesion molecule 1 (sICAM-1), soluble vascular cell adhesion molecule 1 (sVCAM-1), monocyte chemoattractant protein 1 (MCP-1) and impaired nitric oxide production in human umbilical vein endothelial cells (HUVECs), all of which are early events occurring in atherogenesis. We showed that CTS significantly suppressed TNF-α-induced increased endothelial permeability, monocyte adhesion, sICAM-1, sVCAM-1 and MCP-1, and restored nitric oxide production. These observations suggest that CTS possesses anti-inflammatory properties and could be a promising treatment for the prevention of cytokine-induced early atherogenesis.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 18%
Student > Bachelor 3 18%
Lecturer 1 6%
Professor 1 6%
Researcher 1 6%
Other 0 0%
Unknown 8 47%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 3 18%
Medicine and Dentistry 2 12%
Biochemistry, Genetics and Molecular Biology 1 6%
Social Sciences 1 6%
Neuroscience 1 6%
Other 0 0%
Unknown 9 53%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 April 2016.
All research outputs
#19,495,804
of 23,975,976 outputs
Outputs from The Journal of Physiological Sciences
#221
of 321 outputs
Outputs of similar age
#292,703
of 400,564 outputs
Outputs of similar age from The Journal of Physiological Sciences
#8
of 11 outputs
Altmetric has tracked 23,975,976 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 321 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 400,564 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.