↓ Skip to main content

Cryptotanshinone inhibits TNF-α-induced early atherogenic events in vitro.

Overview of attention for article published in Journal of Physiological Sciences, January 2016
Altmetric Badge

Mentioned by

twitter
1 tweeter
facebook
1 Facebook page

Citations

dimensions_citation
10 Dimensions

Readers on

mendeley
5 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Cryptotanshinone inhibits TNF-α-induced early atherogenic events in vitro.
Published in
Journal of Physiological Sciences, January 2016
DOI 10.1007/s12576-015-0410-7
Pubmed ID
Authors

Ahmad, Zuraini, Ng, Chin Theng, Fong, Lai Yen, Bakar, Nurul Ain Abu, Hussain, Nor Hayuti Mohd, Ang, Kok Pian, Ee, Gwendoline Cheng Lian, Hakim, Muhammad Nazrul, Zuraini Ahmad, Chin Theng Ng, Lai Yen Fong, Nurul Ain Abu Bakar, Nor Hayuti Mohd Hussain, Kok Pian Ang, Gwendoline Cheng Lian Ee, Muhammad Nazrul Hakim

Abstract

Endothelial dysfunction has been implicated in the pathogenesis of atherosclerosis. Salvia miltiorrhiza (danshen) is a traditional Chinese medicine that has been effectively used to treat cardiovascular disease. Cryptotanshinone (CTS), a major lipophilic compound isolated from S. miltiorrhiza, has been reported to possess cardioprotective effects. However, the anti-atherogenic effects of CTS, particularly on tumor necrosis factor-α (TNF-α)-induced endothelial cell activation, are still unclear. This study aimed to determine the effect of CTS on TNF-α-induced increased endothelial permeability, monocyte adhesion, soluble intercellular adhesion molecule 1 (sICAM-1), soluble vascular cell adhesion molecule 1 (sVCAM-1), monocyte chemoattractant protein 1 (MCP-1) and impaired nitric oxide production in human umbilical vein endothelial cells (HUVECs), all of which are early events occurring in atherogenesis. We showed that CTS significantly suppressed TNF-α-induced increased endothelial permeability, monocyte adhesion, sICAM-1, sVCAM-1 and MCP-1, and restored nitric oxide production. These observations suggest that CTS possesses anti-inflammatory properties and could be a promising treatment for the prevention of cytokine-induced early atherogenesis.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 5 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 5 100%

Demographic breakdown

Readers by professional status Count As %
Professor 1 20%
Lecturer 1 20%
Student > Bachelor 1 20%
Student > Ph. D. Student 1 20%
Researcher 1 20%
Other 0 0%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 3 60%
Unspecified 1 20%
Neuroscience 1 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 April 2016.
All research outputs
#5,735,219
of 7,578,098 outputs
Outputs from Journal of Physiological Sciences
#95
of 145 outputs
Outputs of similar age
#215,566
of 310,769 outputs
Outputs of similar age from Journal of Physiological Sciences
#6
of 10 outputs
Altmetric has tracked 7,578,098 research outputs across all sources so far. This one is in the 13th percentile – i.e., 13% of other outputs scored the same or lower than it.
So far Altmetric has tracked 145 research outputs from this source. They receive a mean Attention Score of 3.1. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 310,769 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.