Cryptotanshinone inhibits TNF-α-induced early atherogenic events in vitro.
Journal of Physiological Sciences, January 2016
Ahmad, Zuraini, Ng, Chin Theng, Fong, Lai Yen, Bakar, Nurul Ain Abu, Hussain, Nor Hayuti Mohd, Ang, Kok Pian, Ee, Gwendoline Cheng Lian, Hakim, Muhammad Nazrul, Zuraini Ahmad, Chin Theng Ng, Lai Yen Fong, Nurul Ain Abu Bakar, Nor Hayuti Mohd Hussain, Kok Pian Ang, Gwendoline Cheng Lian Ee, Muhammad Nazrul Hakim
Endothelial dysfunction has been implicated in the pathogenesis of atherosclerosis. Salvia miltiorrhiza (danshen) is a traditional Chinese medicine that has been effectively used to treat cardiovascular disease. Cryptotanshinone (CTS), a major lipophilic compound isolated from S. miltiorrhiza, has been reported to possess cardioprotective effects. However, the anti-atherogenic effects of CTS, particularly on tumor necrosis factor-α (TNF-α)-induced endothelial cell activation, are still unclear. This study aimed to determine the effect of CTS on TNF-α-induced increased endothelial permeability, monocyte adhesion, soluble intercellular adhesion molecule 1 (sICAM-1), soluble vascular cell adhesion molecule 1 (sVCAM-1), monocyte chemoattractant protein 1 (MCP-1) and impaired nitric oxide production in human umbilical vein endothelial cells (HUVECs), all of which are early events occurring in atherogenesis. We showed that CTS significantly suppressed TNF-α-induced increased endothelial permeability, monocyte adhesion, sICAM-1, sVCAM-1 and MCP-1, and restored nitric oxide production. These observations suggest that CTS possesses anti-inflammatory properties and could be a promising treatment for the prevention of cytokine-induced early atherogenesis.
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