Title |
Benefits of antioxidant supplements for knee osteoarthritis: rationale and reality
|
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Published in |
Nutrition Journal, January 2016
|
DOI | 10.1186/s12937-015-0115-z |
Pubmed ID | |
Authors |
Ashok Kumar Grover, Sue E. Samson |
Abstract |
Arthritis causes disability due to pain and inflammation in joints. There are many forms of arthritis, one of which is osteoarthritis whose prevalence increases with age. It occurs in various joints including hip, knee and hand with knee osteoarthritis being more prevalent. There is no cure for it. The management strategies include exercise, glucosamine plus chondroitin sulfate and NSAIDs. In vitro and animal studies provide a rationale for the use of antioxidant supplements for its management. This review assesses the reality of the benefits of antioxidant supplements in the management of knee osteoarthritis. Several difficulties were encountered in examining this issue: poorly conducted studies, a lack of uniformity in disease definition and diagnosis, and muddling of conclusions from attempts to isolate the efficacious molecules. The antioxidant supplements with most evidence for benefit for pain relief and function in knee osteoarthritis were based on curcumin and avocado-soya bean unsaponifiables. Boswellia and some herbs used in Ayurvedic and Chinese medicine may also be useful. The benefits of cuisines with the appropriate antioxidants should be assessed because they may be more economical and easier to incorporate into the lifestyle. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 6 | 67% |
Canada | 1 | 11% |
Bosnia and Herzegovina | 1 | 11% |
Unknown | 1 | 11% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 7 | 78% |
Practitioners (doctors, other healthcare professionals) | 2 | 22% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Portugal | 1 | <1% |
Australia | 1 | <1% |
Belgium | 1 | <1% |
Japan | 1 | <1% |
United States | 1 | <1% |
Unknown | 358 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 60 | 17% |
Student > Master | 54 | 15% |
Student > Ph. D. Student | 28 | 8% |
Researcher | 25 | 7% |
Student > Doctoral Student | 21 | 6% |
Other | 58 | 16% |
Unknown | 117 | 32% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 73 | 20% |
Nursing and Health Professions | 48 | 13% |
Agricultural and Biological Sciences | 26 | 7% |
Biochemistry, Genetics and Molecular Biology | 22 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 18 | 5% |
Other | 52 | 14% |
Unknown | 124 | 34% |