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Nop17 is a key R2TP factor for the assembly and maturation of box C/D snoRNP complex

Overview of attention for article published in BMC Molecular Biology, March 2015
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Title
Nop17 is a key R2TP factor for the assembly and maturation of box C/D snoRNP complex
Published in
BMC Molecular Biology, March 2015
DOI 10.1186/s12867-015-0037-5
Pubmed ID
Authors

Marcela B Prieto, Raphaela C Georg, Fernando A Gonzales-Zubiate, Juliana S Luz, Carla C Oliveira

Abstract

Box C/D snoRNPs are responsible for rRNA methylation and processing, and are formed by snoRNAs and four conserved proteins, Nop1, Nop56, Nop58 and Snu13. The snoRNP assembly is a stepwise process, involving other protein complexes, among which the R2TP and Hsp90 chaperone. Nop17, also known as Pih1, has been shown to be a constituent of the R2TP (Rvb1, Rvb2, Tah1, Pih1) and to participate in box C/D snoRNP assembly by its interaction with Nop58. The molecular function of Nop17, however, has not yet been described. To shed light on the role played by Nop17 in the maturation of snoRNP, here we analyzed the interactions domains of Nop58 - Nop17 - Tah1 and the importance of ATP to the interaction between Nop17 and the ATPase Rvb1/2. Based on the results shown here, we propose a model for the assembly of box C/D snoRNP, according to which R2TP complex is important for reducing the affinity of Nop58 for snoRNA, and for the binding of the other snoRNP subunits.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 27 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 37%
Student > Master 6 22%
Researcher 4 15%
Student > Bachelor 2 7%
Professor > Associate Professor 2 7%
Other 2 7%
Unknown 1 4%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 48%
Biochemistry, Genetics and Molecular Biology 10 37%
Environmental Science 1 4%
Veterinary Science and Veterinary Medicine 1 4%
Psychology 1 4%
Other 0 0%
Unknown 1 4%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 January 2016.
All research outputs
#7,173,114
of 8,295,152 outputs
Outputs from BMC Molecular Biology
#149
of 181 outputs
Outputs of similar age
#266,835
of 320,201 outputs
Outputs of similar age from BMC Molecular Biology
#6
of 9 outputs
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So far Altmetric has tracked 181 research outputs from this source. They receive a mean Attention Score of 2.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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