Title |
New insights into the regulation of innate immunity by caspase-8
|
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Published in |
Arthritis Research & Therapy, January 2016
|
DOI | 10.1186/s13075-015-0910-0 |
Pubmed ID | |
Authors |
Vitaliya Sagulenko, Kate E. Lawlor, James E. Vince |
Abstract |
Caspase-8 is required for extrinsic apoptosis, but is also central for preventing a pro-inflammatory receptor interacting protein kinase (RIPK) 3-mixed lineage kinase domain-like (MLKL)-dependent cell death pathway termed necroptosis. Despite these critical cellular functions, the impact of capase-8 deletion in the myeloid cell lineage, which forms the basis for innate immune responses, has remained unclear. In a recent article in Arthritis Research & Therapy, Cuda et al. report that myeloid cell-restricted caspase-8 loss leads to a very mild RIPK3-dependent inflammatory phenotype. The presented results suggest that inflammation does not arise exclusively because of RIPK3-mediated necroptotic death but that, in the absence of caspase-8, RIPK1 and RIPK3 enhance microbiome-driven Toll-like receptor-induced pro-inflammatory cytokine production. |
X Demographics
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 6 | 24% |
Student > Ph. D. Student | 4 | 16% |
Researcher | 3 | 12% |
Student > Doctoral Student | 3 | 12% |
Other | 2 | 8% |
Other | 4 | 16% |
Unknown | 3 | 12% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 8 | 32% |
Agricultural and Biological Sciences | 5 | 20% |
Medicine and Dentistry | 4 | 16% |
Immunology and Microbiology | 3 | 12% |
Chemistry | 1 | 4% |
Other | 0 | 0% |
Unknown | 4 | 16% |