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Decreased expression of 17β-hydroxysteroid dehydrogenase type 1 is associated with DNA hypermethylation in colorectal cancer located in the proximal colon

Overview of attention for article published in BMC Cancer, December 2011
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Title
Decreased expression of 17β-hydroxysteroid dehydrogenase type 1 is associated with DNA hypermethylation in colorectal cancer located in the proximal colon
Published in
BMC Cancer, December 2011
DOI 10.1186/1471-2407-11-522
Pubmed ID
Authors

Agnieszka Anna Rawłuszko, Karolina Horbacka, Piotr Krokowicz, Paweł Piotr Jagodziński

Abstract

The importance of 17β-estradiol (E2) in the prevention of large bowel tumorigenesis has been shown in many epidemiological studies. Extragonadal E2 may form by the aromatase pathway from androstenedione or the sulfatase pathway from estrone (E1) sulfate followed by E1 reduction to E2 by 17-β-hydroxysteroid dehydrogenase (HSD17B1), so HSD17B1 gene expression may play an important role in the production of E2 in peripheral tissue, including the colon.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 1 5%
Unknown 18 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 42%
Student > Bachelor 3 16%
Other 2 11%
Student > Doctoral Student 1 5%
Lecturer > Senior Lecturer 1 5%
Other 2 11%
Unknown 2 11%
Readers by discipline Count As %
Medicine and Dentistry 7 37%
Biochemistry, Genetics and Molecular Biology 4 21%
Agricultural and Biological Sciences 4 21%
Computer Science 1 5%
Unknown 3 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 December 2011.
All research outputs
#15,239,825
of 22,659,164 outputs
Outputs from BMC Cancer
#4,098
of 8,238 outputs
Outputs of similar age
#162,659
of 242,888 outputs
Outputs of similar age from BMC Cancer
#43
of 88 outputs
Altmetric has tracked 22,659,164 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,238 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 242,888 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 88 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.