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Immunomodulatory effect of mesenchymal stem cells

Overview of attention for article published in Einstein (São Paulo), June 2011
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1 tweeter

Citations

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8 Dimensions

Readers on

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15 Mendeley
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Title
Immunomodulatory effect of mesenchymal stem cells
Published in
Einstein (São Paulo), June 2011
DOI 10.1590/s1679-45082011rw1843
Pubmed ID
Authors

Luciana Cavalheiro Marti, Andreza Alice Feitosa Ribeiro, Nelson Hamerschlak

Abstract

Mesenchymal stem cells represent an adult population of nonhematopoietic cells, which can differentiate into a variety of cell types such as osteocytes, chondrocytes, adipocytes, and myocytes. They display immunomodulatory properties that have led to the consideration of their use for the inhibition of immune responses. In this context, mesenchymal stem cells efficiently inhibit maturation, cytokine production, and the T cell stimulatory capacity of dendritic cells. They also can impair proliferation, cytokine secretion, and cytotoxic potential of T lymphocytes. Moreover, mesenchymal stem cells are able to inhibit the differentiation of B cells to plasma cells by inhibiting their capacity to produce antibodies. A variety of animal models confirm the immunomodulatory properties of mesenchymal stem cells. Clinical studies including patients with severe acute graft-versus-host disease have revealed that the administration of mesenchymal stem cells results in significant clinical responses. Therefore, mesenchymal stem cells improve acute graft-versus-host disease and represent a promising candidate for the prevention and treatment of immune-mediated diseases, due to their immunomodulatory capability and their low immunogenicity.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 27%
Student > Ph. D. Student 2 13%
Student > Master 2 13%
Student > Bachelor 1 7%
Professor 1 7%
Other 1 7%
Unknown 4 27%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 27%
Medicine and Dentistry 2 13%
Agricultural and Biological Sciences 1 7%
Economics, Econometrics and Finance 1 7%
Veterinary Science and Veterinary Medicine 1 7%
Other 1 7%
Unknown 5 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 January 2016.
All research outputs
#5,213,131
of 6,977,329 outputs
Outputs from Einstein (São Paulo)
#38
of 64 outputs
Outputs of similar age
#209,762
of 306,139 outputs
Outputs of similar age from Einstein (São Paulo)
#5
of 5 outputs
Altmetric has tracked 6,977,329 research outputs across all sources so far. This one is in the 14th percentile – i.e., 14% of other outputs scored the same or lower than it.
So far Altmetric has tracked 64 research outputs from this source. They receive a mean Attention Score of 1.7. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 306,139 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one.