Title |
Serum levels of brain-derived neurotrophic factor (BDNF), proBDNF and plasma 3-methoxy-4-hydroxyphenylglycol levels in chronic schizophrenia
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Published in |
Annals of General Psychiatry, January 2016
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DOI | 10.1186/s12991-015-0084-9 |
Pubmed ID | |
Authors |
Reiji Yoshimura, Hikaru Hori, Asuka Katsuki, Kiyokazu Atake, Jun Nakamura |
Abstract |
We investigated the serum levels of brain-derived neurotrophic factor (BDNF), proBDNF and plasma 3-methoxy-4-hydroxyphenylglycol (MHPG) levels in patients with chronic schizophrenia. Sixty-eight patients who met the DSM-IV-TR criteria and had a chronic schizophrenia (CS) duration of ≥ 5 years were enrolled. Their serum brain-derived BDNF and proBDNF levels were measured by enzyme-linked immunosorbent assays, and their plasma MHPG levels were analyzed by high-performance liquid chromatography with electrochemical detection. The plasma MHPG levels were significantly lower in the CS group (3.9 ± 1.8 ng/ml) compared to those in the group of 32 age- and sex-matched healthy controls (5.1 ± 2.4 ng/ml). The serum BDNF levels were significantly lower in the CS group (8.9 ± 4.8 ng/ml) compared to the control group (12.2.1 ± 6.8 ng/ml). No correlation was observed between plasma MHPG and BDNF in the CS group. These results suggest that hypo-activity of noradrenergic neurons and decreased BDNF secretion exist in chronic schizophrenic patients. |
X Demographics
Geographical breakdown
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 32 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 7 | 22% |
Student > Ph. D. Student | 6 | 19% |
Researcher | 5 | 16% |
Student > Doctoral Student | 3 | 9% |
Other | 2 | 6% |
Other | 5 | 16% |
Unknown | 4 | 13% |
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Neuroscience | 9 | 28% |
Medicine and Dentistry | 6 | 19% |
Psychology | 3 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
Nursing and Health Professions | 1 | 3% |
Other | 3 | 9% |
Unknown | 8 | 25% |