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Effect of nitrous oxide on fentanyl consumption in burned patients undergoing dressing change

Overview of attention for article published in Brazilian Journal of Anesthesiology (English edition), January 2016
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Effect of nitrous oxide on fentanyl consumption in burned patients undergoing dressing change
Published in
Brazilian Journal of Anesthesiology (English edition), January 2016
DOI 10.1016/j.bjane.2014.07.016
Pubmed ID

Arthur Halley Barbosa do Vale, Rogério Luiz da Rocha Videira, David Souza Gomez, Maria José Carvalho Carmona, Sara Yume Tsuchie, Cláudia Flório, Matheus Fachini Vane, Irimar de Paula Posso


Thermal injuries and injured areas management are important causes of pain in burned patients, requiring that these patients are constantly undergoing general anesthesia for dressing change. Nitrous oxide (N2O) has analgesic and sedative properties; it is easy to use and widely available. Thus, the aim of this study was to evaluate the analgesic effect of N2O combined with fentanyl in burned patients during dressing change. After approval by the institutional Ethics Committee, 15 adult burned patients requiring daily dressing change were evaluated. Patient analgesia was controlled with fentanyl 0.0005% administered by intravenous pump infusion on-demand. Randomly, in one of the days a mixture of 65% N2O in oxygen (O2) was associated via mask, with a flow of 10L/min (N2O group) and on the other day only O2 under the same flow (control group). No significant pain reduction was seen in N2O group compared to control group. VAS score before dressing change was 4.07 and 3.4, respectively, in N2O and control groups. Regarding pain at the end of the dressing, patients in N2O group reported pain severity of 2.8; while the control group reported 2.87. There was no significant difference in fentanyl consumption in both groups. The association of N2O was not effective in reducing opioid consumption during dressing changes.

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 40 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 6 15%
Other 6 15%
Student > Master 4 10%
Lecturer 2 5%
Researcher 2 5%
Other 6 15%
Unknown 14 35%
Readers by discipline Count As %
Medicine and Dentistry 15 38%
Nursing and Health Professions 6 15%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Agricultural and Biological Sciences 1 3%
Biochemistry, Genetics and Molecular Biology 1 3%
Other 2 5%
Unknown 14 35%