Title |
Effects of a novel method of anesthesia combining propofol and volatile anesthesia on the incidence of postoperative nausea and vomiting in patients undergoing laparoscopic gynecological surgery
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Published in |
Brazilian Journal of Anesthesiology, October 2014
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DOI | 10.1016/j.bjane.2014.07.005 |
Pubmed ID | |
Authors |
Hiroaki Kawano, Naohiro Ohshita, Kimiko Katome, Takako Kadota, Michiko Kinoshita, Yayoi Matsuoka, Yasuo M. Tsutsumi, Shinji Kawahito, Katsuya Tanaka, Shuzo Oshita |
Abstract |
We investigated the effects of a novel method of anesthesia combining propofol and volatile anesthesia on the incidence of postoperative nausea and vomiting in patients undergoing laparoscopic gynecological surgery. Patients were randomly divided into three groups: those maintained with sevoflurane (Group S, n=42), propofol (Group P, n=42), or combined propofol and sevoflurane (Group PS, n=42). We assessed complete response (no postoperative nausea and vomiting and no rescue antiemetic use), incidence of nausea and vomiting, nausea severity score, vomiting frequency, rescue antiemetic use, and postoperative pain at 2 and 24h after surgery. The number of patients who exhibited a complete response was greater in Groups P and PS than in Group S at 0-2h (74%, 76% and 43%, respectively, p=0.001) and 0-24h (71%, 76% and 38%, respectively, p<0.0005). The incidence of nausea at 0-2h (Group S=57%, Group P=26% and Group PS=21%, p=0.001) and 0-24h (Group S=62%, Group P=29% and Group PS=21%, p<0.0005) was also significantly different among groups. However, there were no significant differences among groups in the incidence or frequency of vomiting or rescue antiemetic use at 0-24h. Combined propofol and volatile anesthesia during laparoscopic gynecological surgery effectively decreases the incidence of postoperative nausea. We term this novel method of anesthesia "combined intravenous-volatile anesthesia (CIVA)". |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
Unknown | 42 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 7 | 16% |
Student > Bachelor | 6 | 14% |
Student > Master | 5 | 12% |
Student > Doctoral Student | 5 | 12% |
Researcher | 4 | 9% |
Other | 10 | 23% |
Unknown | 6 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 19 | 44% |
Nursing and Health Professions | 11 | 26% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 7% |
Biochemistry, Genetics and Molecular Biology | 2 | 5% |
Social Sciences | 1 | 2% |
Other | 1 | 2% |
Unknown | 6 | 14% |