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Induction of broad immunity by thermostabilised vaccines incorporated in dissolvable microneedles using novel fabrication methods

Overview of attention for article published in Journal of Controlled Release, March 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)
  • High Attention Score compared to outputs of the same age and source (95th percentile)

Mentioned by

news
2 news outlets
twitter
7 tweeters
patent
3 patents

Citations

dimensions_citation
58 Dimensions

Readers on

mendeley
75 Mendeley
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Title
Induction of broad immunity by thermostabilised vaccines incorporated in dissolvable microneedles using novel fabrication methods
Published in
Journal of Controlled Release, March 2016
DOI 10.1016/j.jconrel.2016.01.019
Pubmed ID
Authors

Anto Vrdoljak, Evin A. Allen, Francesca Ferrara, Nigel J. Temperton, Abina M. Crean, Anne C. Moore

Abstract

Dissolvable microneedle (DMN) patches for immunization have multiple benefits, including vaccine stability and ease-of-use. However, conventional DMN fabrication methods have several drawbacks. Here we describe a novel, microfluidic, drop dispensing-based dissolvable microneedle production method that overcomes these issues. Uniquely, heterogeneous arrays, consisting of microneedles of diverse composition, can be easily produced on the same patch. Robustness of the process was demonstrated by incorporating and stabilizing adenovirus and MVA vaccines. Clinically-available trivalent inactivated influenza vaccine (TIV) in DMN patches is fully stable for greater than 6months at 40°C. Immunization using low dose TIV-loaded DMN patches induced significantly higher antibody responses compared to intramuscular-based immunization in mice. TIV-loaded patches also induced a broader, heterosubtypic neutralizing antibody response. By addressing issues that will be faced in large-scale fill-finish DMN fabrication processes and demonstrating superior thermostable characteristics and immunogenicity, this study progresses the translation of this microneedle platform to eventual clinical deployment.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 4%
Unknown 72 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 16%
Researcher 11 15%
Student > Master 11 15%
Student > Bachelor 9 12%
Student > Doctoral Student 7 9%
Other 14 19%
Unknown 11 15%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 14 19%
Engineering 11 15%
Agricultural and Biological Sciences 8 11%
Medicine and Dentistry 7 9%
Immunology and Microbiology 5 7%
Other 16 21%
Unknown 14 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 27. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 September 2021.
All research outputs
#979,388
of 19,044,106 outputs
Outputs from Journal of Controlled Release
#121
of 7,999 outputs
Outputs of similar age
#21,460
of 356,816 outputs
Outputs of similar age from Journal of Controlled Release
#5
of 120 outputs
Altmetric has tracked 19,044,106 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,999 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 356,816 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 120 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.