Title |
Novel technologies and emerging biomarkers for personalized cancer immunotherapy
|
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Published in |
Journal for Immunotherapy of Cancer, January 2016
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DOI | 10.1186/s40425-016-0107-3 |
Pubmed ID | |
Authors |
Jianda Yuan, Priti S. Hegde, Raphael Clynes, Periklis G. Foukas, Alexandre Harari, Thomas O. Kleen, Pia Kvistborg, Cristina Maccalli, Holden T. Maecker, David B. Page, Harlan Robins, Wenru Song, Edward C. Stack, Ena Wang, Theresa L. Whiteside, Yingdong Zhao, Heinz Zwierzina, Lisa H. Butterfield, Bernard A. Fox |
Abstract |
The culmination of over a century's work to understand the role of the immune system in tumor control has led to the recent advances in cancer immunotherapies that have resulted in durable clinical responses in patients with a variety of malignancies. Cancer immunotherapies are rapidly changing traditional treatment paradigms and expanding the therapeutic landscape for cancer patients. However, despite the current success of these therapies, not all patients respond to immunotherapy and even those that do often experience toxicities. Thus, there is a growing need to identify predictive and prognostic biomarkers that enhance our understanding of the mechanisms underlying the complex interactions between the immune system and cancer. Therefore, the Society for Immunotherapy of Cancer (SITC) reconvened an Immune Biomarkers Task Force to review state of the art technologies, identify current hurdlers, and make recommendations for the field. As a product of this task force, Working Group 2 (WG2), consisting of international experts from academia and industry, assembled to identify and discuss promising technologies for biomarker discovery and validation. Thus, this WG2 consensus paper will focus on the current status of emerging biomarkers for immune checkpoint blockade therapy and discuss novel technologies as well as high dimensional data analysis platforms that will be pivotal for future biomarker research. In addition, this paper will include a brief overview of the current challenges with recommendations for future biomarker discovery. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 8 | 67% |
Comoros | 1 | 8% |
Unknown | 3 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 9 | 75% |
Science communicators (journalists, bloggers, editors) | 2 | 17% |
Practitioners (doctors, other healthcare professionals) | 1 | 8% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 5 | <1% |
France | 3 | <1% |
Germany | 1 | <1% |
Belgium | 1 | <1% |
Iran, Islamic Republic of | 1 | <1% |
Russia | 1 | <1% |
Korea, Republic of | 1 | <1% |
Unknown | 510 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 139 | 27% |
Student > Ph. D. Student | 83 | 16% |
Other | 56 | 11% |
Student > Master | 43 | 8% |
Student > Bachelor | 43 | 8% |
Other | 75 | 14% |
Unknown | 84 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 101 | 19% |
Biochemistry, Genetics and Molecular Biology | 98 | 19% |
Agricultural and Biological Sciences | 89 | 17% |
Immunology and Microbiology | 42 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 32 | 6% |
Other | 62 | 12% |
Unknown | 99 | 19% |