Title |
Coupled transcriptome and proteome analysis of human lymphotropic tumor viruses: insights on the detection and discovery of viral genes
|
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Published in |
BMC Genomics, December 2011
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DOI | 10.1186/1471-2164-12-625 |
Pubmed ID | |
Authors |
Lindsay R Dresang, Jeremy R Teuton, Huichen Feng, Jon M Jacobs, David G Camp, Samuel O Purvine, Marina A Gritsenko, Zhihua Li, Richard D Smith, Bill Sugden, Patrick S Moore, Yuan Chang |
Abstract |
Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV) are related human tumor viruses that cause primary effusion lymphomas (PEL) and Burkitt's lymphomas (BL), respectively. Viral genes expressed in naturally-infected cancer cells contribute to disease pathogenesis; knowing which viral genes are expressed is critical in understanding how these viruses cause cancer. To evaluate the expression of viral genes, we used high-resolution separation and mass spectrometry coupled with custom tiling arrays to align the viral proteomes and transcriptomes of three PEL and two BL cell lines under latent and lytic culture conditions. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Germany | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
Unknown | 43 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 12 | 27% |
Student > Ph. D. Student | 8 | 18% |
Professor > Associate Professor | 4 | 9% |
Student > Bachelor | 3 | 7% |
Student > Master | 2 | 5% |
Other | 5 | 11% |
Unknown | 10 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 19 | 43% |
Biochemistry, Genetics and Molecular Biology | 6 | 14% |
Immunology and Microbiology | 2 | 5% |
Computer Science | 2 | 5% |
Engineering | 2 | 5% |
Other | 3 | 7% |
Unknown | 10 | 23% |