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Quality of life in mild dementia: patterns of change in self and caregiver ratings over time

Overview of attention for article published in Revista Brasileira de Psiquiatria, January 2016
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Title
Quality of life in mild dementia: patterns of change in self and caregiver ratings over time
Published in
Revista Brasileira de Psiquiatria, January 2016
DOI 10.1590/1516-4446-2014-1642
Pubmed ID
Authors

Marcia C. Dourado, Maria F. de Sousa, Raquel L. Santos, José P. Simões Neto, Marcela L. Nogueira, Tatiana T. Belfort, Bianca Torres, Rachel Dias, Jerson Laks

Abstract

To determine changes over time in self and caregiver ratings of quality of life (QoL) in people with dementia (PwD) and to identify factors associated with changes in QoL ratings. In this longitudinal study, 69 people with mild Alzheimer's disease and their caregivers were assessed at baseline and after 1 year. We examined the association of QoL ratings with the following variables at the two time points: awareness of disease, cognitive status, mood, functionality, neuropsychiatric symptoms, and caregiver burden. Multivariate regression analyses were conducted to examine the contribution of co-factors. At baseline, PwD self-ratings of QoL were associated with caregiver ratings of PwD QoL (p = 0.001). Caregiver ratings were associated with PwD mood (p = 0.001) and self-rated QoL (p = 0.001). After 1 year, caregiver ratings of PwD QoL changed significantly (p = 0.049, d = -0.27), whereas PwD self-ratings did not (p = 0.89, d = 0.09). PwD awareness of disease changed significantly (p = 0.001) at 1 year, having declined in 25.4% and improved in 12.3% of participants. PwD QoL self-ratings were associated with caregiver ratings (p = 0.001). Caregiver ratings of PwD QoL after 1 year were associated with PwD mood (p = 0.029), self-reported QoL (p = 0.001), and awareness of disease (p = 0.033). The association between self and caregiver ratings of PwD QoL was maintained over 1 year. The primary factors accounting for the change in caregiver ratings were PwD mood and awareness of disease. QoL and cognitive impairment seem to be relatively independent in mild dementia.

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Mendeley readers

The data shown below were compiled from readership statistics for 96 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 96 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 14 15%
Student > Ph. D. Student 13 14%
Student > Bachelor 12 13%
Researcher 7 7%
Professor 6 6%
Other 19 20%
Unknown 25 26%
Readers by discipline Count As %
Psychology 21 22%
Nursing and Health Professions 16 17%
Medicine and Dentistry 14 15%
Neuroscience 6 6%
Social Sciences 3 3%
Other 7 7%
Unknown 29 30%