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Change in knee structure and change in tibiofemoral joint space width: a five year longitudinal population–based study

Overview of attention for article published in BMC Musculoskeletal Disorders, January 2016
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Title
Change in knee structure and change in tibiofemoral joint space width: a five year longitudinal population–based study
Published in
BMC Musculoskeletal Disorders, January 2016
DOI 10.1186/s12891-016-0879-0
Pubmed ID
Authors

Joanna Hall, Laura L. Laslett, Johanne Martel-Pelletier, Jean-Pierre Pelletier, François Abram, Chang-Hai Ding, Flavia M. Cicuttini, Graeme Jones

Abstract

Change in knee cartilage volume is frequently used as a proxy for change in knee joint space width over time, but longitudinal data on these associations is limited. We aimed to determine whether change in knee cartilage volume, new or worsening meniscal extrusion (ME), meniscal tears and cartilage defects over 2.4 years correlated with change in joint space width (JSW) over 5 years in older community dwelling adults. Participants (n = 153) had their right knee imaged using MR imaging and x-ray at baseline, and after 2.4 years (MRI) and 5 years (x-ray). Cartilage volume, cartilage defects, meniscal extrusions and meniscal tears were assessed on sagittal T1-weighted fat-suppressed MRI. JSW was assessed using standard fixed semi-flexed view radiographs, and scored on those with adequate alignment. Participants were 51-79 (mean 62) years old; 48 % were female. Cartilage volume reduced over time (medial -134 ± 202 μL/year, lateral -106 ± 165 μL/year, p < 0.001), as did JSW (medial -0.05 ± 0.16 mm/year, lateral -0.12 ± 0.24 mm/year, p < 0.001). In multivariable analysis, the only consistent predictor of change in JSW was new or worsening ME (medial tibia R(2) 3.1 %, p = 0.031; medial femur R(2) 3.2 %, p = 0.024); change in cartilage volume correlated with change in JSW laterally (R(2) 4.8 %, p = 0.007) and was borderline medially (R(2) 2.2 %, p = 0.064); there was no association for meniscal tears or cartilage defects. The magnitude of these associations were similar albeit somewhat greater for ME in participants with radiographic OA (R(2) 6.2 %, p = 0.017). Change in ME and cartilage volume weakly predict change in JSW, but the vast majority of the variation remains unexplained. Since MRI examines cartilage directly while radiographs examine it indirectly, these results cast doubt on the validity of using JSW as a proxy measure of cartilage loss.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 37 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 16%
Other 4 11%
Student > Master 4 11%
Student > Doctoral Student 3 8%
Researcher 2 5%
Other 5 14%
Unknown 13 35%
Readers by discipline Count As %
Medicine and Dentistry 12 32%
Engineering 3 8%
Nursing and Health Professions 2 5%
Arts and Humanities 1 3%
Agricultural and Biological Sciences 1 3%
Other 1 3%
Unknown 17 46%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 January 2016.
All research outputs
#18,436,183
of 22,840,638 outputs
Outputs from BMC Musculoskeletal Disorders
#3,130
of 4,046 outputs
Outputs of similar age
#285,886
of 395,719 outputs
Outputs of similar age from BMC Musculoskeletal Disorders
#69
of 83 outputs
Altmetric has tracked 22,840,638 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,046 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
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We're also able to compare this research output to 83 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.