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Folic acid targeted Mn:ZnS quantum dots for theranostic applications of cancer cell imaging and therapy

Overview of attention for article published in International Journal of Nanomedicine, January 2016
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (63rd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (59th percentile)

Mentioned by

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5 tweeters

Citations

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49 Dimensions

Readers on

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74 Mendeley
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Title
Folic acid targeted Mn:ZnS quantum dots for theranostic applications of cancer cell imaging and therapy
Published in
International Journal of Nanomedicine, January 2016
DOI 10.2147/ijn.s90198
Pubmed ID
Authors

Faruq Mohammad, Ibrahim birma Bwatanglang, Nor Azah Yusof, Jaafar Abdullah, Mohd Zobir Hussein, Noorjahan Banu Alitheen, Nadiah Abu

Abstract

In this study, we synthesized a multifunctional nanoparticulate system with specific targeting, imaging, and drug delivering functionalities by following a three-step protocol that operates at room temperature and solely in aqueous media. The synthesis involves the encapsulation of luminescent Mn:ZnS quantum dots (QDs) with chitosan not only as a stabilizer in biological environment, but also to further provide active binding sites for the conjugation of other biomolecules. Folic acid was incorporated as targeting agent for the specific targeting of the nanocarrier toward the cells overexpressing folate receptors. Thus, the formed composite emits orange-red fluorescence around 600 nm and investigated to the highest intensity at Mn(2+) doping concentration of 15 at.% and relatively more stable at low acidic and low alkaline pH levels. The structural characteristics and optical properties were thoroughly analyzed by using Fourier transform infrared, X-ray diffraction, dynamic light scattering, ultraviolet-visible, and fluorescence spectroscopy. Further characterization was conducted using thermogravimetric analysis, high-resolution transmission electron microscopy, field emission scanning electron microscopy, energy dispersive X-ray spectroscopy, X-ray fluorescence, and X-ray photoelectron spectroscopy. The cell viability and proliferation studies by means of MTT assay have demonstrated that the as-synthesized composites do not exhibit any toxicity toward the human breast cell line MCF-10 (noncancer) and the breast cancer cell lines (MCF-7 and MDA-MB-231) up to a 500 µg/mL concentration. The cellular uptake of the nanocomposites was assayed by confocal laser scanning microscope by taking advantage of the conjugated Mn:ZnS QDs as fluorescence makers. The result showed that the functionalization of the chitosan-encapsulated QDs with folic acid enhanced the internalization and binding affinity of the nanocarrier toward folate receptor-overexpressed cells. Therefore, we hypothesized that due to the nontoxic nature of the composite, the as-synthesized nanoparticulate system can be used as a promising candidate for theranostic applications, especially for a simultaneous targeted drug delivery and cellular imaging.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 74 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 19%
Student > Master 10 14%
Student > Ph. D. Student 10 14%
Student > Bachelor 6 8%
Student > Doctoral Student 5 7%
Other 19 26%
Unknown 10 14%
Readers by discipline Count As %
Chemistry 17 23%
Materials Science 8 11%
Pharmacology, Toxicology and Pharmaceutical Science 8 11%
Medicine and Dentistry 5 7%
Agricultural and Biological Sciences 5 7%
Other 18 24%
Unknown 13 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 February 2016.
All research outputs
#2,798,758
of 7,168,681 outputs
Outputs from International Journal of Nanomedicine
#269
of 1,663 outputs
Outputs of similar age
#113,228
of 319,127 outputs
Outputs of similar age from International Journal of Nanomedicine
#27
of 77 outputs
Altmetric has tracked 7,168,681 research outputs across all sources so far. This one has received more attention than most of these and is in the 60th percentile.
So far Altmetric has tracked 1,663 research outputs from this source. They receive a mean Attention Score of 2.1. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 319,127 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.
We're also able to compare this research output to 77 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.