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ShockOmics: multiscale approach to the identification of molecular biomarkers in acute heart failure induced by shock

Overview of attention for article published in Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, January 2016
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Title
ShockOmics: multiscale approach to the identification of molecular biomarkers in acute heart failure induced by shock
Published in
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, January 2016
DOI 10.1186/s13049-016-0197-4
Pubmed ID
Authors

Federico Aletti, Costanza Conti, Manuela Ferrario, Vicent Ribas, Bernardo Bollen Pinto, Antoine Herpain, Emiel Post, Eduardo Romay Medina, Cristina Barlassina, Eliandre de Oliveira, Roberta Pastorelli, Gabriella Tedeschi, Giuseppe Ristagno, Fabio S. Taccone, Geert W. Schmid-Schönbein, Ricard Ferrer, Daniel De Backer, Karim Bendjelid, Giuseppe Baselli

Abstract

The ShockOmics study (ClinicalTrials.gov identifier NCT02141607) is a multicenter prospective observational trial aimed at identifying new biomarkers of acute heart failure in circulatory shock, by means of a multiscale analysis of blood samples and hemodynamic data from subjects with circulatory shock. Ninety septic shock and cardiogenic shock patients will be recruited in three intensive care units (ICU) (Hôpital Erasme, Université Libre de Bruxelles, Belgium; Hospital Universitari Mutua Terrassa, Spain; Hôpitaux Universitaires de Genève, Switzerland). Hemodynamic signals will be recorded every day for up to seven days from shock diagnosis (time T0). Clinical data and blood samples will be collected for analysis at: i) T1 < 16 h from T0; ii) T2 = 48 h after T0; iii) T3 = day 7 or before discharge or before discontinuation of therapy in case of fatal outcome; iv) T4 = day 100. The inclusion criteria are: shock, Sequential Organ Failure Assessment (SOFA) score > 5 and lactate levels ≥ 2 mmol/L. The exclusion criteria are: expected death within 24 h since ICU admission; > 4 units of red blood cells or >1 fresh frozen plasma transfused; active hematological malignancy; metastatic cancer; chronic immunodepression; pre-existing end stage renal disease requiring renal replacement therapy; recent cardiac surgery; Child-Pugh C cirrhosis; terminal illness. Enrollment will be preceded by the signature of the Informed Consent by the patient or his/her relatives and by the physician in charge. Three non-shock control groups will be included in the study: a) healthy blood donors (n = 5); b) septic patients (n = 10); c) acute myocardial infarction or patients with prolonged acute arrhythmia (n = 10). The hemodynamic data will be downloaded from the ICU monitors by means of dedicated software. The blood samples will be utilized for transcriptomics, proteomics and metabolomics ("-omics") analyses. ShockOmics will provide new insights into the pathophysiological mechanisms underlying shock as well as new biomarkers for the timely diagnosis of cardiac dysfunction in shock and quantitative indices for assisting the therapeutic management of shock patients.

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Mendeley readers

Mendeley readers

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Geographical breakdown

Country Count As %
Brazil 1 1%
Unknown 79 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 16%
Student > Ph. D. Student 11 14%
Student > Bachelor 10 13%
Student > Master 7 9%
Student > Doctoral Student 4 5%
Other 17 21%
Unknown 18 23%
Readers by discipline Count As %
Medicine and Dentistry 36 45%
Engineering 4 5%
Biochemistry, Genetics and Molecular Biology 4 5%
Nursing and Health Professions 3 4%
Agricultural and Biological Sciences 3 4%
Other 6 8%
Unknown 24 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 January 2016.
All research outputs
#20,303,950
of 22,842,950 outputs
Outputs from Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
#1,213
of 1,258 outputs
Outputs of similar age
#333,477
of 396,721 outputs
Outputs of similar age from Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
#30
of 31 outputs
Altmetric has tracked 22,842,950 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,258 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.