Title |
Preparation, characterization, and potential application of chitosan, chitosan derivatives, and chitosan metal nanoparticles in pharmaceutical drug delivery
|
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Published in |
Drug Design, Development and Therapy, January 2016
|
DOI | 10.2147/dddt.s99651 |
Pubmed ID | |
Authors |
Tarek A Ahmed, Bader M Aljaeid |
Abstract |
Naturally occurring polymers, particularly of the polysaccharide type, have been used pharmaceutically for the delivery of a wide variety of therapeutic agents. Chitosan, the second abundant naturally occurring polysaccharide next to cellulose, is a biocompatible and biodegradable mucoadhesive polymer that has been extensively used in the preparation of micro-as well as nanoparticles. The prepared particles have been exploited as a potential carrier for different therapeutic agents such as peptides, proteins, vaccines, DNA, and drugs for parenteral and nonparenteral administration. Therapeutic agent-loaded chitosan micro- or nanoparticles were found to be more stable, permeable, and bioactive. In this review, we are highlighting the different methods of preparation and characterization of chitosan micro- and nanoparticles, while reviewing the pharmaceutical applications of these particles in drug delivery. Moreover, the roles of chitosan derivatives and chitosan metal nanoparticles in drug delivery have been illustrated. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Russia | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | <1% |
France | 1 | <1% |
Unknown | 899 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 133 | 15% |
Student > Ph. D. Student | 130 | 14% |
Student > Bachelor | 99 | 11% |
Researcher | 71 | 8% |
Student > Doctoral Student | 46 | 5% |
Other | 120 | 13% |
Unknown | 302 | 34% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 122 | 14% |
Chemistry | 93 | 10% |
Biochemistry, Genetics and Molecular Biology | 74 | 8% |
Agricultural and Biological Sciences | 64 | 7% |
Engineering | 48 | 5% |
Other | 154 | 17% |
Unknown | 346 | 38% |