Is Alpha-Synuclein Loss-of-Function a Contributor to Parkinsonian Pathology? Evidence from Non-human Primates

@GeneticsMike7 Yes, APP knockout (https://t.co/khdWOvQrz1) and SNCA knockdown (https://t.co/fW4xdQxwln) induce degeneration and phenotype.

@GeneticsMike7 @AlbertoEspay In experimental models, local depletion was shown to result in neurodegeneration both for abeta https://t.co/N1icjgEE4b and alpha-synuclein in PD https://t.co/BVq95NDb3P

@FactorH8 We began, Ignacio, but had to create a company (@RegainNeuro) because the prevailing narrative prevents competing ideas from review bodies at NIH and other funding agencies. Here is an example of key data that didn't earn follow-up funding: https

@BillDauerNeuro @MichaelOkun @PdAvengers @endingpdbook @ParkinsonDotOrg Here are the data from non-human primates: https://t.co/SEqKJuJ7oR There is no follow-up because these scientists couldn't get their grants funded by the NIH. These data do not fit t