Title |
Isolation, characterization, and in vitro propagation of infantile hemangioma stem cells and an in vivo mouse model
|
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Published in |
Journal of Hematology & Oncology, December 2011
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DOI | 10.1186/1756-8722-4-54 |
Pubmed ID | |
Authors |
Dan Xu, Teresa M O, Archil Shartava, Taylor C Fowles, Jianchang Yang, Louis M Fink, David C Ward, Martin C Mihm, Milton Waner, Yupo Ma |
Abstract |
Infantile hemangiomas (IH) are the most common benign tumors of infancy. The typical clinical course consists of rapid growth during the first year of life, followed by natural and gradual involution over a multi-year time span through unknown cellular mechanisms. Some tumors respond to medical treatment with corticosteroids or beta-blockers, however, when this therapy fails or is incomplete, surgical extirpation may be necessary. Noninvasive therapies to debulk or eliminate these tumors would be an important advance. The development of an in vitro cell culture system and an animal model would allow new insights into the biological processes involved in the development and pathogenesis of IH. |
X Demographics
Geographical breakdown
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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France | 1 | 4% |
Unknown | 27 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Doctoral Student | 6 | 21% |
Other | 3 | 11% |
Researcher | 3 | 11% |
Student > Ph. D. Student | 3 | 11% |
Student > Bachelor | 2 | 7% |
Other | 5 | 18% |
Unknown | 6 | 21% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 15 | 54% |
Agricultural and Biological Sciences | 5 | 18% |
Neuroscience | 1 | 4% |
Engineering | 1 | 4% |
Unknown | 6 | 21% |