↓ Skip to main content

Quantitative structure retention/activity relationships of biologically relevant 4-amino-7-chloroquinoline based compounds

Overview of attention for article published in Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences, February 2016
Altmetric Badge

Mentioned by

twitter
1 tweeter

Citations

dimensions_citation
12 Dimensions

Readers on

mendeley
26 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Quantitative structure retention/activity relationships of biologically relevant 4-amino-7-chloroquinoline based compounds
Published in
Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences, February 2016
DOI 10.1016/j.jchromb.2016.01.033
Pubmed ID
Authors

Sandra Šegan, Igor Opsenica, Mario Zlatović, Dušanka Milojković-Opsenica, Bogdan Šolaja

Abstract

The chromatographic behaviour of series of 4-amino-7-chloroquinoline (4,7-ACQ) based compounds was studied by reversed-phase thin-layer chromatography (RPTLC) with binary mobile phases containing water and the organic modifiers, DMSO or acetone. The lipophilicity of the studied compounds was determined by extrapolation of retention parameters RM to pure water content in mobile phase. In order to obtain some basic insight into the chromatographic behaviour and structural features of investigated compounds, PCA was performed on both chromatographic data (RM values) and calculated 2D and 3D structural descriptors. Both QSRR and QSAR models were built by means of the partial least squares (PLS) statistical method. It was found that descriptors which encode hydrophobic (dispersive) interactions have positive influence on retention, while influence of descriptors encoding polar interactions was negative. According to the obtained PLS model for inhibition of botulinum neurotoxin serotype A light chain, hydrophobic interactions influence positively on the mechanism of action of the investigated 4,7-ACQ, while polar interactions are less favoured. Contrary, the results of PLS modelling of activity against Plasmodium falciparum strains (W2, D6 and TM91C235) indicate that higher polarity of 4,7-ACQ contribute to their higher antimalarial activity.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 26 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 38%
Professor > Associate Professor 4 15%
Professor 2 8%
Researcher 2 8%
Student > Doctoral Student 1 4%
Other 1 4%
Unknown 6 23%
Readers by discipline Count As %
Chemistry 12 46%
Environmental Science 1 4%
Biochemistry, Genetics and Molecular Biology 1 4%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Medicine and Dentistry 1 4%
Other 1 4%
Unknown 9 35%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 February 2016.
All research outputs
#18,437,241
of 22,842,950 outputs
Outputs from Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
#2,363
of 3,806 outputs
Outputs of similar age
#287,662
of 397,369 outputs
Outputs of similar age from Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
#24
of 39 outputs
Altmetric has tracked 22,842,950 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,806 research outputs from this source. They receive a mean Attention Score of 2.5. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 397,369 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.