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Interleukin-6 Is a Risk Factor for Atrial Fibrillation in Chronic Kidney Disease: Findings from the CRIC Study

Overview of attention for article published in PLOS ONE, February 2016
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (63rd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (57th percentile)

Mentioned by

twitter
5 tweeters
reddit
1 Redditor

Citations

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35 Dimensions

Readers on

mendeley
65 Mendeley
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Title
Interleukin-6 Is a Risk Factor for Atrial Fibrillation in Chronic Kidney Disease: Findings from the CRIC Study
Published in
PLOS ONE, February 2016
DOI 10.1371/journal.pone.0148189
Pubmed ID
Authors

Richard L. Amdur, Monica Mukherjee, Alan Go, Ian R. Barrows, Ali Ramezani, Jun Shoji, Muredach P. Reilly, Joseph Gnanaraj, Raj Deo, Sylvia Roas, Martin Keane, Steve Master, Valerie Teal, Elsayed Z. Soliman, Peter Yang, Harold Feldman, John W. Kusek, Cynthia M. Tracy, Dominic S. Raj

Abstract

Atrial fibrillation (AF) is the most common sustained arrhythmia in patients with chronic kidney disease (CKD). In this study, we examined the association between inflammation and AF in 3,762 adults with CKD, enrolled in the Chronic Renal Insufficiency Cohort (CRIC) study. AF was determined at baseline by self-report and electrocardiogram (ECG). Plasma concentrations of interleukin(IL)-1, IL-1 Receptor antagonist, IL-6, tumor necrosis factor (TNF)-α, transforming growth factor-β, high sensitivity C-Reactive protein, and fibrinogen, measured at baseline. At baseline, 642 subjects had history of AF, but only 44 had AF in ECG recording. During a mean follow-up of 3.7 years, 108 subjects developed new-onset AF. There was no significant association between inflammatory biomarkers and past history of AF. After adjustment for demographic characteristics, comorbid conditions, laboratory values, echocardiographic variables, and medication use, plasma IL-6 level was significantly associated with presence of AF at baseline (Odds ratio [OR], 1.61; 95% confidence interval [CI], 1.21 to 2.14; P = 0.001) and new-onset AF (OR, 1.25; 95% CI, 1.02 to 1.53; P = 0.03). To summarize, plasma IL-6 level is an independent and consistent predictor of AF in patients with CKD.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Sri Lanka 1 2%
Brazil 1 2%
Unknown 63 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 10 15%
Researcher 9 14%
Student > Master 9 14%
Student > Ph. D. Student 8 12%
Other 5 8%
Other 16 25%
Unknown 8 12%
Readers by discipline Count As %
Medicine and Dentistry 33 51%
Agricultural and Biological Sciences 6 9%
Biochemistry, Genetics and Molecular Biology 5 8%
Nursing and Health Professions 2 3%
Pharmacology, Toxicology and Pharmaceutical Science 2 3%
Other 5 8%
Unknown 12 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 February 2016.
All research outputs
#7,872,255
of 15,173,603 outputs
Outputs from PLOS ONE
#65,164
of 153,551 outputs
Outputs of similar age
#122,345
of 341,754 outputs
Outputs of similar age from PLOS ONE
#2,137
of 5,183 outputs
Altmetric has tracked 15,173,603 research outputs across all sources so far. This one is in the 47th percentile – i.e., 47% of other outputs scored the same or lower than it.
So far Altmetric has tracked 153,551 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.8. This one has gotten more attention than average, scoring higher than 56% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,754 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.
We're also able to compare this research output to 5,183 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.