↓ Skip to main content

A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly

Overview of attention for article published in Proceedings of the National Academy of Sciences of the United States of America, April 2010
Altmetric Badge

About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (87th percentile)

Mentioned by

news
1 news outlet
blogs
4 blogs
googleplus
1 Google+ user
f1000
1 research highlight platform

Citations

dimensions_citation
164 Dimensions

Readers on

mendeley
211 Mendeley
citeulike
2 CiteULike
Title
A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly
Published in
Proceedings of the National Academy of Sciences of the United States of America, April 2010
DOI 10.1073/pnas.0910878107
Pubmed ID
Authors

A. J. Ho, J. L. Stein, X. Hua, S. Lee, D. P. Hibar, A. D. Leow, I. D. Dinov, A. W. Toga, A. J. Saykin, L. Shen, T. Foroud, N. Pankratz, M. J. Huentelman, D. W. Craig, J. D. Gerber, A. N. Allen, J. J. Corneveaux, D. A. Stephan, C. S. DeCarli, B. M. DeChairo, S. G. Potkin, C. R. Jack, M. W. Weiner, C. A. Raji, O. L. Lopez, J. T. Becker, O. T. Carmichael, P. M. Thompson, M. Weiner, L. Thal, R. Petersen, C. R. Jack, W. Jagust, J. Trojanowki, A. W. Toga, L. Beckett, R. C. Green, A. Gamst, W. Z. Potter, T. Montine, D. Anders, M. Bernstein, J. Felmlee, N. Fox, P. Thompson, N. Schuff, G. Alexander, D. Bandy, R. A. Koeppe, N. Foster, E. M. Reiman, K. Chen, J. Trojanowki, L. Shaw, V. M.- Y. Lee, M. Korecka, A. W. Toga, K. Crawford, S. Neu, D. Harvey, A. Gamst, J. Kornak, Z. Kachaturian, R. Frank, P. J. Snyder, S. Molchan, J. Kaye, R. Vorobik, J. Quinn, L. Schneider, S. Pawluczyk, B. Spann, A. S. Fleisher, H. Vanderswag, J. L. Heidebrink, J. L. Lord, K. Johnson, R. S. Doody, J. Villanueva-Meyer, M. Chowdhury, Y. Stern, L. S. Honig, K. L. Bell, J. C. Morris, M. A. Mintun, S. Schneider, D. Marson, R. Griffith, B. Badger, H. Grossman, C. Tang, J. Stern, L. deToledo-Morrell, R. C. Shah, J. Bach, R. Duara, R. Isaacson, S. Strauman, M. S. Albert, J. Pedroso, J. Toroney, H. Rusinek, M. J. de Leon, S. M. De Santi, P. M. Doraiswamy, J. R. Petrella, M. Aiello, C. M. Clark, C. Pham, J. Nunez, C. D. Smith, C. A. Given II, P. Hardy, S. T. DeKosky, M. Oakley, D. M. Simpson, M. S. Ismail, A. Porsteinsson, C. McCallum, S. C. Cramer, R. A. Mulnard, C. McAdams-Ortiz, R. Diaz-Arrastia, K. Martin-Cook, M. DeVous, A. I. Levey, J. J. Lah, J. S. Cellar, J. M. Burns, H. S. Anderson, M. M. Laubinger, G. Bartzokis, D. H. S. Silverman, P. H. Lu, R. Fletcher, F. Parfitt, H. Johnson, M. Farlow, S. Herring, A. M. Hake, C. H. van Dyck, M. G. MacAvoy, L. A. Bifano, H. Chertkow, H. Bergman, C. Hosein, S. Black, S. Graham, C. Caldwell, H. Feldman, M. Assaly, G.-Y. R. Hsiung, A. Kertesz, J. Rogers, D. Trost, C. Bernick, D. Gitelman, N. Johnson, M. Mesulam, C. Sadowsky, T. Villena, S. Mesner, P. S. Aisen, K. B. Johnson, K. E. Behan, R. A. Sperling, D. M. Rentz, K. A. Johnson, A. Rosen, J. Tinklenberg, W. Ashford, M. Sabbagh, D. Connor, S. Obradov, R. Killiany, A. Norbash, T. O. Obisesan, A. Jayam-Trouth, P. Wang, A. P. Auchus, J. Huang, R. P. Friedland, C. DeCarli, E. Fletcher, O. Carmichael, S. Kittur, S. Mirje, S. C. Johnson, M. Borrie, T.-Y. Lee, S. Asthana, C. M. Carlsson, S. G. Potkin, D. Highum, A. Preda, D. Nguyen, P. N. Tariot, B. A. Hendin, D. W. Scharre, M. Kataki, D. Q. Beversdorf, E. A. Zimmerman, D. Celmins, A. D. Brown, S. Gandy, M. E. Marenberg, B. W. Rovner, G. Pearlson, K. Blank, K. Anderson, A. J. Saykin, R. B. Santulli, N. Pare, J. D. Williamson, K. M. Sink, H. Potter, B. Ashok Raj, A. Giordano, B. R. Ott, C.-K. Wu, R. Cohen, K. L. Wilks

Abstract

A recently identified variant within the fat mass and obesity-associated (FTO) gene is carried by 46% of Western Europeans and is associated with an approximately 1.2 kg higher weight, on average, in adults and an approximately 1 cm greater waist circumference. With >1 billion overweight and 300 million obese persons worldwide, it is crucial to understand the implications of carrying this very common allele for the health of our aging population. FTO is highly expressed in the brain and elevated body mass index (BMI) is associated with brain atrophy, but it is unknown how the obesity-associated risk allele affects human brain structure. We therefore generated 3D maps of regional brain volume differences in 206 healthy elderly subjects scanned with MRI and genotyped as part of the Alzheimer's Disease Neuroimaging Initiative. We found a pattern of systematic brain volume deficits in carriers of the obesity-associated risk allele versus noncarriers. Relative to structure volumes in the mean template, FTO risk allele carriers versus noncarriers had an average brain volume difference of approximately 8% in the frontal lobes and 12% in the occipital lobes-these regions also showed significant volume deficits in subjects with higher BMI. These brain differences were not attributable to differences in cholesterol levels, hypertension, or the volume of white matter hyperintensities; which were not detectably higher in FTO risk allele carriers versus noncarriers. These brain maps reveal that a commonly carried susceptibility allele for obesity is associated with structural brain atrophy, with implications for the health of the elderly.

Mendeley readers

The data shown below were compiled from readership statistics for 211 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 14 7%
Switzerland 2 <1%
Germany 2 <1%
Netherlands 2 <1%
United Kingdom 2 <1%
Brazil 1 <1%
Egypt 1 <1%
Norway 1 <1%
Australia 1 <1%
Other 3 1%
Unknown 182 86%

Demographic breakdown

Readers by professional status Count As %
Researcher 52 25%
Student > Ph. D. Student 42 20%
Professor 19 9%
Professor > Associate Professor 17 8%
Student > Master 17 8%
Other 64 30%
Readers by discipline Count As %
Agricultural and Biological Sciences 48 23%
Medicine and Dentistry 46 22%
Psychology 33 16%
Unspecified 23 11%
Neuroscience 19 9%
Other 42 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 33. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 May 2017.
All research outputs
#515,740
of 13,595,345 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#9,911
of 80,696 outputs
Outputs of similar age
#5,415
of 210,805 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#90
of 743 outputs
Altmetric has tracked 13,595,345 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 80,696 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.4. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 210,805 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 743 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.