You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
Mendeley readers
Attention Score in Context
| Title |
SADB phosphorylation of γ-tubulin regulates centrosome duplication
|
|---|---|
| Published in |
Nature Cell Biology, August 2009
|
| DOI | 10.1038/ncb1921 |
| Pubmed ID | |
| Authors |
María Alvarado-Kristensson, María Josefa Rodríguez, Virginia Silió, José M. Valpuesta, Ana C. Carrera |
| Abstract |
Symmetrical cell division requires duplication of DNA and protein content to generate two daughter cells. Centrosomes also duplicate during cell division, but the mechanism controlling this process is incompletely understood. We describe an alternative splice form of SadB encoding a short SADB Ser/Thr kinase whose activity fluctuates during the cell cycle, localizes to centrosomes, and controls centrosome duplication. Reduction of endogenous SADB levels diminished centrosome numbers, whereas enhanced SADB expression induced centrosome amplification. SADB exerted this action through phosphorylation of gamma-tubulin on Ser 131, as expression of a phosphomimetic Ser 131-to-Asp gamma-tubulin mutant alone increased centrosome numbers, whereas non-phosphorylatable Ala 131-gamma-tubulin impaired centrosome duplication. We propose that SADB kinase activity controls centrosome homeostasis by regulating phosphorylation of gamma-tubulin. |
Mendeley readers
The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 1% |
| United States | 1 | 1% |
| Canada | 1 | 1% |
| Unknown | 73 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 25 | 33% |
| Student > Ph. D. Student | 21 | 28% |
| Student > Bachelor | 7 | 9% |
| Professor > Associate Professor | 4 | 5% |
| Student > Postgraduate | 3 | 4% |
| Other | 7 | 9% |
| Unknown | 9 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 33 | 43% |
| Biochemistry, Genetics and Molecular Biology | 20 | 26% |
| Unspecified | 2 | 3% |
| Neuroscience | 2 | 3% |
| Engineering | 2 | 3% |
| Other | 6 | 8% |
| Unknown | 11 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 September 2017.
All research outputs
#6,377,613
of 22,660,862 outputs
Outputs from Nature Cell Biology
#2,231
of 3,812 outputs
Outputs of similar age
#32,706
of 110,461 outputs
Outputs of similar age from Nature Cell Biology
#16
of 35 outputs
Altmetric has tracked 22,660,862 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 3,812 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.0. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 110,461 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.