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CEACAM1 negatively regulates platelet-collagen interactions and thrombus growth in vitro and in vivo

Overview of attention for article published in Blood, February 2009
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36 Mendeley
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Title
CEACAM1 negatively regulates platelet-collagen interactions and thrombus growth in vitro and in vivo
Published in
Blood, February 2009
DOI 10.1182/blood-2008-06-165043
Pubmed ID
Authors

Cyndi Wong, Yong Liu, Jana Yip, Rochna Chand, Janet L. Wee, Lisa Oates, Bernhard Nieswandt, Adili Reheman, Heyu Ni, Nicole Beauchemin, Denise E. Jackson

Abstract

Carcinoembryonic antigen cell adhesion molecule-1 (CEACAM1) is a surface glycoprotein expressed on various blood cells, epithelial cells, and vascular cells. CEACAM1 possesses adhesive and signaling properties mediated by its intrinsic immunoreceptor tyrosine-based inhibitory motifs that recruit SHP-1 protein-tyrosine phosphatase. In this study, we demonstrate that CEACAM1 is expressed on the surface and in intracellular pools of platelets. In addition, CEACAM1 serves to negatively regulate signaling of platelets by collagen through the glycoprotein VI (GPVI)/Fc receptor (FcR)-gamma-chain. ceacam1(-/-) platelets displayed enhanced type I collagen and GPVI-selective ligand, collagen-related peptide (CRP), CRP-mediated platelet aggregation, enhanced platelet adhesion on type I collagen, and elevated CRP-mediated alpha and dense granule secretion. Platelets derived from ceacam1(-/-) mice form larger thrombi when perfused over a collagen matrix under arterial flow compared with wild-type mice. Furthermore, using intravital microscopy to ferric chloride-injured mesenteric arterioles, we show that thrombi formed in vivo in ceacam1(-/-) mice were larger and were more stable than those in wild-type mice. GPVI depletion using monoclonal antibody JAQ1 treatment of ceacam1(-/-) mice showed a reversal in the more stable thrombus growth phenotype. ceacam1(-/-) mice were more susceptible to type I collagen-induced pulmonary thromboembolism than wild-type mice. Thus, CEACAM1 acts as a negative regulator of platelet-collagen interactions and of thrombus growth involving the collagen GPVI receptor in vitro and in vivo.

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 3%
Unknown 35 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 33%
Student > Ph. D. Student 7 19%
Student > Doctoral Student 5 14%
Student > Master 5 14%
Student > Bachelor 3 8%
Other 2 6%
Unknown 2 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 33%
Medicine and Dentistry 7 19%
Biochemistry, Genetics and Molecular Biology 6 17%
Arts and Humanities 1 3%
Nursing and Health Professions 1 3%
Other 4 11%
Unknown 5 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 January 2009.
All research outputs
#7,761,740
of 12,371,951 outputs
Outputs from Blood
#12,851
of 16,574 outputs
Outputs of similar age
#117,296
of 222,225 outputs
Outputs of similar age from Blood
#373
of 676 outputs
Altmetric has tracked 12,371,951 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 16,574 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 222,225 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 676 others from the same source and published within six weeks on either side of this one. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.