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Safety and immunogenicity, after nasal application of HIV-1 DNA gagp37 plasmid vaccine in young mice

Overview of attention for article published in Vaccine, September 2008
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  • Average Attention Score compared to outputs of the same age

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Citations

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15 Mendeley
Title
Safety and immunogenicity, after nasal application of HIV-1 DNA gagp37 plasmid vaccine in young mice
Published in
Vaccine, September 2008
DOI 10.1016/j.vaccine.2008.03.098
Pubmed ID
Authors

Jorma Hinkula, Marie Hagbom, Britta Wahren, Ulf Schroder

Abstract

There is a need for safe and potent adjuvants capable of delivering vaccine candidates over the mucosal barrier, with good capacity to stimulate both mucosal and systemic cell-mediated and humoral immunity. An adjuvant aimed for intranasal delivery should preferably deliver the antigen and minimize the transfer into the close proximity of the central nervous system, thus avoiding damage on the olfactory tissues. Advantages with a mucosal delivery route would be to provide mucosal and systemic immunity, requiring lower vaccine doses then when given parentally. The aim of this study was to study if the N3 adjuvant intranasally administered with HIV DNA plasmids would be transferred into the olfactory tissues and cause local inflammation and tissue damage.

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 7%
Unknown 14 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 67%
Student > Master 2 13%
Student > Ph. D. Student 1 7%
Professor 1 7%
Professor > Associate Professor 1 7%
Other 0 0%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 40%
Immunology and Microbiology 4 27%
Medicine and Dentistry 3 20%
Unspecified 1 7%
Pharmacology, Toxicology and Pharmaceutical Science 1 7%
Other 0 0%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 July 2008.
All research outputs
#7,667,590
of 12,269,624 outputs
Outputs from Vaccine
#8,452
of 10,554 outputs
Outputs of similar age
#124,161
of 239,546 outputs
Outputs of similar age from Vaccine
#105
of 147 outputs
Altmetric has tracked 12,269,624 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,554 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 239,546 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 147 others from the same source and published within six weeks on either side of this one. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.