Title |
Chikungunya virus adapts to tiger mosquito via evolutionary convergence: a sign of things to come?
|
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Published in |
Virology Journal, February 2008
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DOI | 10.1186/1743-422x-5-33 |
Pubmed ID | |
Authors |
Xavier de Lamballerie, Eric Leroy, Rémi N Charrel, Konstantin Ttsetsarkin, Stephen Higgs, Ernest A Gould |
Abstract |
Since 2004, several million indigenous cases of Chikungunya virus disease occurred in Africa, the Indian Ocean, India, Asia and, recently, Europe. The virus, usually transmitted by Aedes aegypti mosquitoes, has now repeatedly been associated with a new vector, Ae. Albopictus. Analysis of full-length viral sequences reveals three independent events of virus exposure to Ae. Albopictus, each followed by the acquisition of a single adaptive mutation providing selective advantage for transmission by this mosquito. This disconcerting and current unique example of "evolutionary convergence" occurring in nature illustrates rapid pathogen adaptation to ecological perturbation, driven directly as a consequence of human activities. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Venezuela, Bolivarian Republic of | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 1% |
Germany | 2 | <1% |
France | 2 | <1% |
Madagascar | 2 | <1% |
Kenya | 1 | <1% |
Brazil | 1 | <1% |
India | 1 | <1% |
Italy | 1 | <1% |
United Kingdom | 1 | <1% |
Other | 1 | <1% |
Unknown | 282 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 65 | 22% |
Student > Ph. D. Student | 51 | 17% |
Student > Master | 34 | 11% |
Student > Bachelor | 27 | 9% |
Student > Doctoral Student | 17 | 6% |
Other | 50 | 17% |
Unknown | 53 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 105 | 35% |
Medicine and Dentistry | 37 | 12% |
Biochemistry, Genetics and Molecular Biology | 35 | 12% |
Environmental Science | 14 | 5% |
Immunology and Microbiology | 14 | 5% |
Other | 33 | 11% |
Unknown | 59 | 20% |