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Neuronal Ensemble Bursting in the Basal Forebrain Encodes Salience Irrespective of Valence

Overview of attention for article published in Neuron, July 2008
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Title
Neuronal Ensemble Bursting in the Basal Forebrain Encodes Salience Irrespective of Valence
Published in
Neuron, July 2008
DOI 10.1016/j.neuron.2008.04.031
Pubmed ID
Authors

Shih-Chieh Lin, Miguel A.L. Nicolelis

Abstract

Both reward- and punishment-related stimuli are motivationally salient and attract the attention of animals. However, it remains unclear how motivational salience is processed in the brain. Here, we show that both reward- and punishment-predicting stimuli elicited robust bursting of many noncholinergic basal forebrain (BF) neurons in behaving rats. The same BF neurons also responded with similar bursting to primary reinforcement of both valences. Reinforcement responses were modulated by expectation, with surprising reinforcement eliciting stronger BF bursting. We further demonstrate that BF burst firing predicted successful detection of near-threshold stimuli. Together, our results point to the existence of a salience-encoding system independent of stimulus valence. We propose that the encoding of motivational salience by ensemble bursting of noncholinergic BF neurons may improve behavioral performance by affecting the activity of widespread cortical circuits and therefore represents a novel candidate mechanism for top-down attention.

Mendeley readers

The data shown below were compiled from readership statistics for 270 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 16 6%
Switzerland 3 1%
United Kingdom 2 <1%
France 2 <1%
Italy 2 <1%
Singapore 1 <1%
Netherlands 1 <1%
Malta 1 <1%
Russia 1 <1%
Other 2 <1%
Unknown 239 89%

Demographic breakdown

Readers by professional status Count As %
Researcher 85 31%
Student > Ph. D. Student 72 27%
Professor > Associate Professor 26 10%
Student > Master 18 7%
Student > Bachelor 14 5%
Other 42 16%
Unknown 13 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 125 46%
Neuroscience 67 25%
Psychology 26 10%
Medicine and Dentistry 21 8%
Engineering 6 2%
Other 8 3%
Unknown 17 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 August 2008.
All research outputs
#7,688,093
of 12,304,922 outputs
Outputs from Neuron
#6,028
of 7,144 outputs
Outputs of similar age
#124,378
of 239,038 outputs
Outputs of similar age from Neuron
#84
of 102 outputs
Altmetric has tracked 12,304,922 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,144 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.5. This one is in the 5th percentile – i.e., 5% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 239,038 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 102 others from the same source and published within six weeks on either side of this one. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.