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An update and systematic review on the treatment of primary dysmenorrhea

Overview of attention for article published in JBRA Assisted Reproduction, January 2019
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An update and systematic review on the treatment of primary dysmenorrhea
Published in
JBRA Assisted Reproduction, January 2019
DOI 10.5935/1518-0557.20180083
Pubmed ID

Maedeh Sharghi, Shabnam Malekpour Mansurkhani, Damoon Ashtary-Larky, Wesam Kooti, Mehdi Niksefat, Mohammad Firoozbakht, Masoud Behzadifar, Milad Azami, Karo Servatyari, Leila Jouybari


Primary dysmenorrhea is a painful uterine contraction caused by endometrial laceration. Drug therapies and complementary medicine have been used to treat dysmenorrhea. The aim of this study was to investigate and offer an updated perspective on the treatments for dysmenorrhea. The present study was conducted in accordance with the PRISMA checklist for systematic reviews and meta-analyses. The required information was collected based on searches for the following keywords: treatment, primary dysmenorrhea, medicinal plants, chemical drugs, and herbs. Searches were performed on databases Pubmed, Web of Sciences, Scopus, Iran medex, and SID by March 2018 to find literature in the English and Persian languages on this subject without a time limit. This review included 17 papers, 10 of which on complementary medicine, three on drug therapies, and four on acupuncture and acupressure. The largest and smallest samples had 303 and 24 patients, respectively. Length of treatment ranged from one to six months and the measures most commonly used in the studies were the visual analogue scale and clinical efficacy. Reported complications included gastrointestinal events, nausea, vomiting, diarrhea, abdominal pain, and liver and kidney disorders. Medicinal plants, drugs, and acupressure seem to suppress pain by reducing the level of prostaglandins, mediating nitric oxide, increasing beta-endorphin levels, blocking the calcium channel, and enhancing circulatory flow through the uterine pathway. Further trials are required to confirm the benefits of the procedures described and ensure the absence of complications.

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Mendeley readers

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Geographical breakdown

Country Count As %
Unknown 78 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 20 26%
Student > Master 8 10%
Student > Postgraduate 5 6%
Student > Ph. D. Student 5 6%
Lecturer 4 5%
Other 13 17%
Unknown 23 29%
Readers by discipline Count As %
Medicine and Dentistry 24 31%
Nursing and Health Professions 20 26%
Biochemistry, Genetics and Molecular Biology 4 5%
Unspecified 3 4%
Psychology 2 3%
Other 3 4%
Unknown 22 28%