Title |
Common variants in FOXP1 are associated with generalized vitiligo
|
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Published in |
Nature Genetics, June 2010
|
DOI | 10.1038/ng.602 |
Pubmed ID | |
Authors |
Ying Jin, Stanca A Birlea, Pamela R Fain, Christina M Mailloux, Sheri L Riccardi, Katherine Gowan, Paulene J Holland, Dorothy C Bennett, Margaret R Wallace, Wayne T McCormack, E Helen Kemp, David J Gawkrodger, Anthony P Weetman, Mauro Picardo, Giovanni Leone, Alain Taïeb, Thomas Jouary, Khaled Ezzedine, Nanny van Geel, Jo Lambert, Andreas Overbeck, Richard A Spritz |
Abstract |
In a recent genome-wide association study of generalized vitiligo, we identified ten confirmed susceptibility loci. By testing additional loci that showed suggestive association in the genome-wide study, using two replication cohorts of European descent, we observed replicated association of generalized vitiligo with variants at 3p13 encompassing FOXP1 (rs17008723, combined P=1.04x10(-8)) and with variants at 6q27 encompassing CCR6 (rs6902119, combined P=3.94x10(-7)). |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 1% |
Netherlands | 1 | 1% |
Canada | 1 | 1% |
Unknown | 73 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 21 | 28% |
Researcher | 12 | 16% |
Student > Bachelor | 8 | 11% |
Student > Master | 7 | 9% |
Professor | 5 | 7% |
Other | 14 | 18% |
Unknown | 9 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 28 | 37% |
Medicine and Dentistry | 17 | 22% |
Biochemistry, Genetics and Molecular Biology | 13 | 17% |
Environmental Science | 2 | 3% |
Immunology and Microbiology | 2 | 3% |
Other | 4 | 5% |
Unknown | 10 | 13% |