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Specific immunosuppression with inducible Foxp3-transduced polyclonal T cells.

Overview of attention for article published in PLoS Biology, November 2008
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Title
Specific immunosuppression with inducible Foxp3-transduced polyclonal T cells.
Published in
PLoS Biology, November 2008
DOI 10.1371/journal.pbio.0060276
Pubmed ID
Authors

Andersen, Kristian G, Butcher, Tracey, Betz, Alexander G

Abstract

Forkhead box p3 (Foxp3)-expressing regulatory T cells are key mediators of peripheral tolerance suppressing undesirable immune responses. Ectopic expression of Foxp3 confers regulatory T cell phenotype to conventional T cells, lending itself to therapeutic use in the prevention of autoimmunity and transplant rejection. Here, we show that adoptive transfer of polyclonal, wild-type T cells transduced with an inducible form of Foxp3 (iFoxp3) can be used to suppress immune responses on demand. In contrast to Foxp3-transduced cells, iFoxp3-transduced cells home "correctly" into secondary lymphoid organs, where they expand and participate in immune responses. Upon induction of iFoxp3, the cells assume regulatory T cell phenotype and start to suppress the response they initially partook in without causing systemic immunosuppression. We used this approach to suppress collagen-induced arthritis, in which conventional Foxp3-transduced cells failed to show any effect. This provides us with a generally applicable strategy to specifically halt immune responses on demand without prior knowledge of the antigens involved.

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 5%
United States 2 5%
Germany 1 2%
France 1 2%
United Kingdom 1 2%
Italy 1 2%
Mexico 1 2%
Ireland 1 2%
Canada 1 2%
Other 0 0%
Unknown 31 74%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 31%
Student > Ph. D. Student 10 24%
Professor 5 12%
Student > Master 4 10%
Student > Bachelor 3 7%
Other 7 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 25 60%
Medicine and Dentistry 11 26%
Physics and Astronomy 2 5%
Mathematics 1 2%
Biochemistry, Genetics and Molecular Biology 1 2%
Other 2 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 December 2008.
All research outputs
#2,017,275
of 3,628,445 outputs
Outputs from PLoS Biology
#1,952
of 2,410 outputs
Outputs of similar age
#100,318
of 231,889 outputs
Outputs of similar age from PLoS Biology
#71
of 76 outputs
Altmetric has tracked 3,628,445 research outputs across all sources so far. This one is in the 25th percentile – i.e., 25% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,410 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.6. This one is in the 5th percentile – i.e., 5% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 231,889 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 76 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.