Title |
Specific Immunosuppression with Inducible Foxp3-Transduced Polyclonal T cells
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Published in |
PLoS Biology, November 2008
|
DOI | 10.1371/journal.pbio.0060276 |
Pubmed ID | |
Authors |
Kristian G Andersen, Tracey Butcher, Alexander G Betz |
Abstract |
Forkhead box p3 (Foxp3)-expressing regulatory T cells are key mediators of peripheral tolerance suppressing undesirable immune responses. Ectopic expression of Foxp3 confers regulatory T cell phenotype to conventional T cells, lending itself to therapeutic use in the prevention of autoimmunity and transplant rejection. Here, we show that adoptive transfer of polyclonal, wild-type T cells transduced with an inducible form of Foxp3 (iFoxp3) can be used to suppress immune responses on demand. In contrast to Foxp3-transduced cells, iFoxp3-transduced cells home "correctly" into secondary lymphoid organs, where they expand and participate in immune responses. Upon induction of iFoxp3, the cells assume regulatory T cell phenotype and start to suppress the response they initially partook in without causing systemic immunosuppression. We used this approach to suppress collagen-induced arthritis, in which conventional Foxp3-transduced cells failed to show any effect. This provides us with a generally applicable strategy to specifically halt immune responses on demand without prior knowledge of the antigens involved. |
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Geographical breakdown
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France | 1 | 2% |
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Germany | 1 | 2% |
Mexico | 1 | 2% |
Canada | 1 | 2% |
Unknown | 49 | 83% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 19 | 32% |
Student > Ph. D. Student | 17 | 29% |
Student > Master | 6 | 10% |
Professor | 5 | 8% |
Student > Doctoral Student | 4 | 7% |
Other | 8 | 14% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 6 | 10% |
Physics and Astronomy | 2 | 3% |
Other | 4 | 7% |
Unknown | 1 | 2% |