Title |
Krill oil attenuates left ventricular dilatation after myocardial infarction in rats
|
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Published in |
Lipids in Health and Disease, December 2011
|
DOI | 10.1186/1476-511x-10-245 |
Pubmed ID | |
Authors |
Linn E Fosshaug, Rolf K Berge, Jan O Beitnes, Kjetil Berge, Hogne Vik, Pål Aukrust, Lars Gullestad, Leif E Vinge, Erik Øie |
Abstract |
In the western world, heart failure (HF) is one of the most important causes of cardiovascular mortality. Supplement with n-3 polyunsaturated fatty acids (PUFA) has been shown to improve cardiac function in HF and to decrease mortality after myocardial infarction (MI). The molecular structure and composition of n-3 PUFA varies between different marine sources and this may be of importance for their biological effects. Krill oil, unlike fish oil supplements, contains the major part of the n-3 PUFA in the form of phospholipids. This study investigated effects of krill oil on cardiac remodeling after experimental MI. Rats were randomised to pre-treatment with krill oil or control feed 14 days before induction of MI. Seven days post-MI, the rats were examined with echocardiography and rats in the control group were further randomised to continued control feed or krill oil feed for 7 weeks before re-examination with echocardiography and euthanization. |
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Mendeley readers
Geographical breakdown
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