Title |
Non-periodic oscillatory deformation of an actomyosin microdroplet encapsulated within a lipid interface
|
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Published in |
Scientific Reports, January 2016
|
DOI | 10.1038/srep18964 |
Pubmed ID | |
Authors |
Yukinori Nishigami, Hiroaki Ito, Seiji Sonobe, Masatoshi Ichikawa |
Abstract |
Active force generation in living organisms, which is mainly involved in actin cytoskeleton and myosin molecular motors, plays a crucial role in various biological processes. Although the contractile properties of actomyosin have been extensively investigated, their dynamic contribution to a deformable membrane remains unclear because of the cellular complexities and the difficulties associated with in vitro reconstitution. Here, by overcoming these experimental difficulties, we demonstrate the dynamic deformation of a reconstituted lipid interface coupled with self-organized structure of contractile actomyosin. Therein, the lipid interface repeatedly oscillates without any remarkable periods. The oscillatory deformation of the interface is caused by the aster-like three-dimensional hierarchical structure of actomyosin inside the droplet, which is revealed that the oscillation occurs stochastically as a Poisson process. |
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