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Drug Design

Overview of attention for book
Cover of 'Drug Design'

Table of Contents

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    Book Overview
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    Chapter 1 Drug Research: Yesterday, Today, and Tomorrow
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    Chapter 2 In the Beginning, There Was Serendipity
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    Chapter 3 Classical Drug Research
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    Chapter 4 Protein–Ligand Interactions as the Basis for Drug Action
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    Chapter 5 Optical Activity and Biological Effect
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    Chapter 6 The Classical Search for Lead Structures
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    Chapter 7 Screening Technologies for Lead Structure Discovery
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    Chapter 8 Optimization of Lead Structures
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    Chapter 9 Designing Prodrugs
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    Chapter 10 Peptidomimetics
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    Chapter 11 Combinatorics: Chemistry with Big Numbers
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    Chapter 12 Gene Technology in Drug Research
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    Chapter 13 Experimental Methods of Structure Determination
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    Chapter 14 Three-Dimensional Structure of Biomolecules
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    Chapter 15 Molecular Modeling
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    Chapter 16 Conformational Analysis
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    Chapter 17 Pharmacophore Hypotheses and Molecular Comparisons
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    Chapter 18 Quantitative Structure–Activity Relationships
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    Chapter 19 From In Vitro to In Vivo: Optimization of ADME and Toxicology Properties
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    Chapter 20 Protein Modeling and Structure-Based Drug Design
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    Chapter 21 A Case Study: Structure-Based Inhibitor Design for tRNA-Guanine Transglycosylase
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    Chapter 22 How Drugs Act: Concepts for Therapy
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    Chapter 23 Inhibitors of Hydrolases with an Acyl–Enzyme Intermediate
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    Chapter 24 Aspartic Protease Inhibitors
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    Chapter 25 Inhibitors of Hydrolyzing Metalloenzymes
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    Chapter 26 Transferase Inhibitors
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    Chapter 27 Oxidoreductase Inhibitors
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    Chapter 28 Agonists and Antagonists of Nuclear Receptors
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    Chapter 29 Agonists and Antagonists of Membrane-Bound Receptors
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    Chapter 30 Ligands for Channels, Pores, and Transporters
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    Chapter 31 Ligands for Surface Receptors
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    Chapter 32 Biologicals: Peptides, Proteins, Nucleotides, and Macrolides as Drugs
Attention for Chapter 4: Protein–Ligand Interactions as the Basis for Drug Action
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Chapter title
Protein–Ligand Interactions as the Basis for Drug Action
Chapter number 4
Book title
Drug Design
Published by
Springer Berlin Heidelberg, January 2013
DOI 10.1007/978-3-642-17907-5_4
Book ISBNs
978-3-64-217906-8, 978-3-64-217907-5
Authors

Gerhard Klebe, Klebe, Gerhard

Editors

Gerhard Klebe

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Malaysia 1 3%
Unknown 33 97%

Demographic breakdown

Readers by professional status Count As %
Unspecified 5 15%
Researcher 5 15%
Lecturer 4 12%
Student > Ph. D. Student 4 12%
Professor > Associate Professor 3 9%
Other 6 18%
Unknown 7 21%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 8 24%
Unspecified 5 15%
Chemistry 5 15%
Pharmacology, Toxicology and Pharmaceutical Science 2 6%
Engineering 2 6%
Other 3 9%
Unknown 9 26%