| Chapter title |
Glucocorticoids and the Brain: Neural Mechanisms Regulating the Stress Response
|
|---|---|
| Chapter number | 10 |
| Book title |
Glucocorticoid Signaling
|
| Published in |
Advances in experimental medicine and biology, January 2015
|
| DOI | 10.1007/978-1-4939-2895-8_10 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-2894-1, 978-1-4939-2895-8
|
| Authors |
Shawn N. Shirazi, Aaron R. Friedman, Daniela Kaufer, Samuel A. Sakhai, Shirazi, Shawn N., Friedman, Aaron R., Kaufer, Daniela, Sakhai, Samuel A. |
| Abstract |
In this chapter, we describe the central role of the brain in the glucocorticoid mediated stress response. We describe the mechanisms by which the brain gauges the severity of stress, mechanisms of hypothalamic-pituitary-adrenal axis (HPA) regulation, and how various sub-systems of the brain respond to glucocorticoid (GC) signaling to regulate stress behavior. In particular, we focus on the hippocampus, pre-frontal cortex, and amygdala, where GCs can induce a series of changes. Finally, we briefly discuss an apparent paradox in GC signaling: while exposure to glucocorticoids promotes the survival of an organism during acute stress, these same hormones in chronic excess can also cause damage and promote illness. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Colombia | 1 | 2% |
| Unknown | 53 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 30% |
| Student > Bachelor | 8 | 15% |
| Researcher | 7 | 13% |
| Student > Doctoral Student | 3 | 6% |
| Professor | 2 | 4% |
| Other | 4 | 7% |
| Unknown | 14 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 14 | 26% |
| Psychology | 11 | 20% |
| Medicine and Dentistry | 6 | 11% |
| Agricultural and Biological Sciences | 4 | 7% |
| Biochemistry, Genetics and Molecular Biology | 2 | 4% |
| Other | 1 | 2% |
| Unknown | 16 | 30% |