Chapter title |
Alzheimer's Disease, Drosophila melanogaster and Polyphenols.
|
---|---|
Chapter number | 2 |
Book title |
Natural Compounds as Therapeutic Agents for Amyloidogenic Diseases
|
Published in |
Advances in experimental medicine and biology, January 2015
|
DOI | 10.1007/978-3-319-18365-7_2 |
Pubmed ID | |
Book ISBNs |
978-3-31-918364-0, 978-3-31-918365-7
|
Authors |
Jimenez-Del-Rio, Marlene, Velez-Pardo, Carlos, Marlene Jimenez-Del-Rio, Carlos Velez-Pardo |
Editors |
Neville Vassallo |
Abstract |
Alzheimer's disease (AD) is an insidious neurological disorder that affects memory, one of the human brain's main cognitive functions. Around 5.2 million Americans currently have AD, and the number threatens to climb to 7 million by 2020. Our native country, Colombia, is no exception with an estimated 260,000 individuals to be affected by AD in 2020. A large, genetically-isolated community in Antioquia, Colombia, with early-onset familial Alzheimer's disease due to a presenilin-1 mutation is ideally suited for the study of molecular mechanisms of AD, and hence accelerate the discovery of new or alternative treatment approaches. In this regard, polyphenols - also known as polyhydroxyphenols - have shown antioxidant activity, gene regulation, metal chelator and anti-amyloidogenic aggregation effects. However, further in vitro and in vivo investigations are warranted to validate their use in clinical trials. Drosophila melanogaster is increasingly being used as a valid in vivo model of AD. Here, we summarise data published within the past 16 years (1998-2014) on the molecular biology of AD and the use of polyphenols in the fly to understand the molecular actions and feasibility of these compounds in the treatment of AD. |
X Demographics
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United States | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 2% |
Unknown | 57 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 12 | 21% |
Researcher | 10 | 17% |
Student > Ph. D. Student | 7 | 12% |
Student > Master | 6 | 10% |
Student > Postgraduate | 3 | 5% |
Other | 6 | 10% |
Unknown | 14 | 24% |
Readers by discipline | Count | As % |
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Neuroscience | 8 | 14% |
Medicine and Dentistry | 7 | 12% |
Biochemistry, Genetics and Molecular Biology | 6 | 10% |
Psychology | 3 | 5% |
Agricultural and Biological Sciences | 3 | 5% |
Other | 8 | 14% |
Unknown | 23 | 40% |