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Systems Medicine

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Cover of 'Systems Medicine'

Table of Contents

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    Book Overview
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    Chapter 1 Systems Medicine: Sketching the Landscape.
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    Chapter 2 Taking Bioinformatics to Systems Medicine.
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    Chapter 3 Systems Medicine: The Future of Medical Genomics, Healthcare, and Wellness.
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    Chapter 4 Next-Generation Pathology
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    Chapter 5 Training in Systems Approaches for the Next Generation of Life Scientists and Medical Doctors.
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    Chapter 6 Systems Medicine in Pharmaceutical Research and Development.
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    Chapter 7 Systems Medicine and Infection
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    Chapter 8 Systems Medicine for Lung Diseases: Phenotypes and Precision Medicine in Cancer, Infection, and Allergy.
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    Chapter 9 Third-Kind Encounters in Biomedicine: Immunology Meets Mathematics and Informatics to Become Quantitative and Predictive.
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    Chapter 10 Systems Medicine in Oncology: Signaling Network Modeling and New-Generation Decision-Support Systems.
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    Chapter 11 Neurological Diseases from a Systems Medicine Point of View.
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    Chapter 12 Computational Modeling of Human Metabolism and Its Application to Systems Biomedicine.
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    Chapter 13 From Systems Understanding to Personalized Medicine: Lessons and Recommendations Based on a Multidisciplinary and Translational Analysis of COPD.
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    Chapter 14 RNA Systems Biology for Cancer: From Diagnosis to Therapy.
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    Chapter 15 Mathematical Models of Pluripotent Stem Cells: At the Dawn of Predictive Regenerative Medicine.
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    Chapter 16 Network-Assisted Disease Classification and Biomarker Discovery.
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    Chapter 17 Anatomy and Physiology of Multiscale Modeling and Simulation in Systems Medicine.
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    Chapter 18 Mathematical and Statistical Techniques for Systems Medicine: The Wnt Signaling Pathway as a Case Study.
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    Chapter 19 Modeling and Simulation Tools: From Systems Biology to Systems Medicine.
Attention for Chapter 11: Neurological Diseases from a Systems Medicine Point of View.
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Chapter title
Neurological Diseases from a Systems Medicine Point of View.
Chapter number 11
Book title
Systems Medicine
Published in
Methods in molecular biology, January 2016
DOI 10.1007/978-1-4939-3283-2_11
Pubmed ID
Book ISBNs
978-1-4939-3282-5, 978-1-4939-3283-2
Authors

Ostaszewski, Marek, Skupin, Alexander, Balling, Rudi, Marek Ostaszewski, Alexander Skupin, Rudi Balling

Editors

Ulf Schmitz, Olaf Wolkenhauer

Abstract

The difficulty to understand, diagnose, and treat neurological disorders stems from the great complexity of the central nervous system on different levels of physiological granularity. The individual components, their interactions, and dynamics involved in brain development and function can be represented as molecular, cellular, or functional networks, where diseases are perturbations of networks. These networks can become a useful research tool in investigating neurological disorders if they are properly tailored to reflect corresponding mechanisms. Here, we review approaches to construct networks specific for neurological disorders describing disease-related pathology on different scales: the molecular, cellular, and brain level. We also briefly discuss cross-scale network analysis as a necessary integrator of these scales.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Luxembourg 2 10%
Japan 1 5%
Unknown 18 86%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 33%
Librarian 2 10%
Other 2 10%
Student > Doctoral Student 2 10%
Student > Bachelor 2 10%
Other 3 14%
Unknown 3 14%
Readers by discipline Count As %
Computer Science 4 19%
Medicine and Dentistry 4 19%
Biochemistry, Genetics and Molecular Biology 3 14%
Agricultural and Biological Sciences 2 10%
Environmental Science 1 5%
Other 4 19%
Unknown 3 14%