Chapter title |
Neurological Diseases from a Systems Medicine Point of View.
|
---|---|
Chapter number | 11 |
Book title |
Systems Medicine
|
Published in |
Methods in molecular biology, January 2016
|
DOI | 10.1007/978-1-4939-3283-2_11 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3282-5, 978-1-4939-3283-2
|
Authors |
Ostaszewski, Marek, Skupin, Alexander, Balling, Rudi, Marek Ostaszewski, Alexander Skupin, Rudi Balling |
Editors |
Ulf Schmitz, Olaf Wolkenhauer |
Abstract |
The difficulty to understand, diagnose, and treat neurological disorders stems from the great complexity of the central nervous system on different levels of physiological granularity. The individual components, their interactions, and dynamics involved in brain development and function can be represented as molecular, cellular, or functional networks, where diseases are perturbations of networks. These networks can become a useful research tool in investigating neurological disorders if they are properly tailored to reflect corresponding mechanisms. Here, we review approaches to construct networks specific for neurological disorders describing disease-related pathology on different scales: the molecular, cellular, and brain level. We also briefly discuss cross-scale network analysis as a necessary integrator of these scales. |
Mendeley readers
Geographical breakdown
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Luxembourg | 2 | 10% |
Japan | 1 | 5% |
Unknown | 18 | 86% |
Demographic breakdown
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---|---|---|
Researcher | 7 | 33% |
Librarian | 2 | 10% |
Other | 2 | 10% |
Student > Doctoral Student | 2 | 10% |
Student > Bachelor | 2 | 10% |
Other | 3 | 14% |
Unknown | 3 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Computer Science | 4 | 19% |
Medicine and Dentistry | 4 | 19% |
Biochemistry, Genetics and Molecular Biology | 3 | 14% |
Agricultural and Biological Sciences | 2 | 10% |
Environmental Science | 1 | 5% |
Other | 4 | 19% |
Unknown | 3 | 14% |