↓ Skip to main content

Genome Stability and Human Diseases

Overview of attention for book
Cover of 'Genome Stability and Human Diseases'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Coming Full Circle: Cyclin-Dependent Kinases as Anti-cancer Drug Targets
  3. Altmetric Badge
    Chapter 2 Core and Linker Histone Modifications Involved in the DNA Damage Response
  4. Altmetric Badge
    Chapter 3 Chromatin Assembly and Signalling the End of DNA Repair Requires Acetylation of Histone H3 on Lysine 56
  5. Altmetric Badge
    Chapter 4 Structure and Function of Histone H2AX
  6. Altmetric Badge
    Chapter 5 The Initiation Step of Eukaryotic DNA Replication
  7. Altmetric Badge
    Chapter 6 Non-coding RNAs: new players in the field of eukaryotic DNA replication.
  8. Altmetric Badge
    Chapter 7 Function of TopBP1 in Genome Stability
  9. Altmetric Badge
    Chapter 8 Eukaryotic Single-Stranded DNA Binding Proteins: Central Factors in Genome Stability
  10. Altmetric Badge
    Chapter 9 DNA polymerases and mutagenesis in human cancers.
  11. Altmetric Badge
    Chapter 10 DNA Polymerase η, a Key Protein in Translesion Synthesis in Human Cells
  12. Altmetric Badge
    Chapter 11 The Mitochondrial DNA Polymerase in Health and Disease
  13. Altmetric Badge
    Chapter 12 Centromeres: Assembling and Propagating Epigenetic Function
  14. Altmetric Badge
    Chapter 13 Nucleotide Excision Repair in Higher Eukaryotes: Mechanism of Primary Damage Recognition in Global Genome Repair
  15. Altmetric Badge
    Chapter 14 Nonhomologous DNA end joining (NHEJ) and chromosomal translocations in humans.
  16. Altmetric Badge
    Chapter 15 Fluorescence-Based Quantification of Pathway-Specific DNA Double-Strand Break Repair Activities: A Powerful Method for the Analysis of Genome Destabilizing Mechanisms
  17. Altmetric Badge
    Chapter 16 Apoptosis: A Way to Maintain Healthy Individuals
  18. Altmetric Badge
    Chapter 17 The use of transgenic mice in cancer and genome stability research.
Attention for Chapter 9: DNA polymerases and mutagenesis in human cancers.
Altmetric Badge

Mentioned by

twitter
1 tweeter

Citations

dimensions_citation
4 Dimensions

Readers on

mendeley
7 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Chapter title
DNA polymerases and mutagenesis in human cancers.
Chapter number 9
Book title
Genome Stability and Human Diseases
Published in
Sub cellular biochemistry, December 2009
DOI 10.1007/978-90-481-3471-7_9
Pubmed ID
Book ISBNs
978-9-04-813470-0, 978-9-04-813471-7
Authors

Crespan E, Amoroso A, Maga G, Emmanuele Crespan, Alessandra Amoroso, Giovanni Maga

Abstract

DNA polymerases (Pols) act as key players in DNA metabolism. These enzymes are the only biological macromolecules able to duplicate the genetic information stored in the DNA and are absolutely required every time this information has to be copied, as during DNA replication or during DNA repair, when lost or damaged DNA sequences have to be replaced with "original" or "correct" copies. In each DNA repair pathway one or more specific Pols are required. A feature of mammalian DNA repair pathways is their redundancy. The failure of one of these pathways can be compensated by another one. However, several DNA lesions require a specific repair pathway for error free repair. In many tumors one or more DNA repair pathways are affected, leading to error prone repair of some kind of lesions by alternatives routes, thus leading to accumulation of mutations and contributing to genomic instability, a common feature of cancer cell. In this chapter, we present the role of each Pol in genome maintenance and highlight the connections between the malfunctioning of these enzymes and cancer progress.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 14%
Unknown 6 86%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 57%
Student > Ph. D. Student 1 14%
Student > Bachelor 1 14%
Professor 1 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 4 57%
Biochemistry, Genetics and Molecular Biology 3 43%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 August 2012.
All research outputs
#12,606,287
of 15,873,363 outputs
Outputs from Sub cellular biochemistry
#176
of 278 outputs
Outputs of similar age
#95,266
of 130,247 outputs
Outputs of similar age from Sub cellular biochemistry
#3
of 4 outputs
Altmetric has tracked 15,873,363 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 278 research outputs from this source. They receive a mean Attention Score of 3.5. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 130,247 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one.