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Steel factor coordinately regulates the molecular signature and biologic function of hematopoietic stem cells

Overview of attention for article published in Blood, August 2008
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (73rd percentile)
  • Good Attention Score compared to outputs of the same age and source (66th percentile)

Mentioned by

patent
5 patents
f1000
1 research highlight platform

Citations

dimensions_citation
49 Dimensions

Readers on

mendeley
66 Mendeley
citeulike
1 CiteULike
connotea
1 Connotea
Title
Steel factor coordinately regulates the molecular signature and biologic function of hematopoietic stem cells
Published in
Blood, August 2008
DOI 10.1182/blood-2007-10-117820
Pubmed ID
Authors

David G. Kent, Brad J. Dykstra, Jay Cheyne, Elaine Ma, Connie J. Eaves

Abstract

Hematopoietic stem cells (HSCs) regenerated in vivo display sustained differences in their self-renewal and differentiation activities. Variations in Steel factor (SF) signaling are known to affect these functions in vitro, but the cellular and molecular mechanisms involved are not understood. To address these issues, we evaluated highly purified HSCs maintained in single-cell serum-free cultures containing 20 ng/mL IL-11 plus 1, 10, or 300 ng/mL SF. Under all conditions, more than 99% of the cells traversed a first cell cycle with similar kinetics. After 8 hours in the 10 or 300 ng/mL SF conditions, the frequency of HSCs remained unchanged. However, in the next 8 hours (ie, 6 hours before any cell divided), HSC integrity was sustained only in the 300 ng/mL SF cultures. The cells in these cultures also contained significantly higher levels of Bmi1, Lnk, and Ezh2 transcripts but not of several other regulators. Assessment of 21 first division progeny pairs further showed that only those generated in 300 ng/mL SF cultures contained HSCs and pairs of progeny with similar differentiation programs were not observed. Thus, SF signaling intensity can directly and coordinately alter the transcription factor profile and long-term repopulating ability of quiescent HSCs before their first division.

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 3%
United States 1 2%
Canada 1 2%
Unknown 62 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 25 38%
Student > Ph. D. Student 22 33%
Student > Bachelor 5 8%
Professor 3 5%
Student > Doctoral Student 2 3%
Other 7 11%
Unknown 2 3%
Readers by discipline Count As %
Agricultural and Biological Sciences 33 50%
Medicine and Dentistry 11 17%
Biochemistry, Genetics and Molecular Biology 10 15%
Engineering 3 5%
Immunology and Microbiology 2 3%
Other 4 6%
Unknown 3 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 July 2021.
All research outputs
#5,612,183
of 20,114,180 outputs
Outputs from Blood
#10,215
of 29,038 outputs
Outputs of similar age
#59,159
of 243,848 outputs
Outputs of similar age from Blood
#107
of 383 outputs
Altmetric has tracked 20,114,180 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 29,038 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 243,848 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 383 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.