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Exon Skipping

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Cover of 'Exon Skipping'

Table of Contents

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    Book Overview
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    Chapter 1 DNA Diagnostics and Exon Skipping
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    Chapter 2 Exon Skipping
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    Chapter 3 Exon Skipping
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    Chapter 4 Analysis and Interpretation of RNA Splicing Alterations in Genes Involved in Genetic Disorders
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    Chapter 5 Exon Skipping Mutations in Neurofibromatosis
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    Chapter 6 Overview on Applications of Antisense-Mediated Exon Skipping
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    Chapter 7 Overview on DMD Exon Skipping
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    Chapter 8 Overview on AON Design
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    Chapter 9 Optimizing RNA/ENA Chimeric Antisense Oligonucleotides Using In Vitro Splicing
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    Chapter 10 Optimizing antisense oligonucleotides using phosphorodiamidate morpholino oligomers.
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    Chapter 11 Optimizing Splice-Switching Oligomer Sequences Using 2′-O-Methyl Phosphorothioate Chemistry
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    Chapter 12 Exon Skipping Quantification by Real-Time PCR
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    Chapter 13 Antisense-mediated exon skipping to shift alternative splicing to treat cancer.
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    Chapter 14 Antisense-Mediated Exon Skipping to Generate Soluble Receptors
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    Chapter 15 Antisense-Mediated Exon Skipping to Reframe Transcripts
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    Chapter 16 U1 snRNA as an Effective Vector for Stable Expression of Antisense Molecules and for the Inhibition of the Splicing Reaction
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    Chapter 17 Engineering U7snRNA Gene to Reframe Transcripts
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    Chapter 18 Dynamic Fluorescent and Luminescent Reporters for Cell-Based Splicing Screens
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    Chapter 19 Antisense-Mediated Exon-Skipping to Induce Gene Knockdown
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    Chapter 20 Antisense-Mediated Exon Inclusion
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    Chapter 21 Antisense Genes to Induce Exon Inclusion
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    Chapter 22 Using Mini-genes to Identify Factors That Modulate Alternative Splicing
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    Chapter 23 Overview of alternative oligonucleotide chemistries for exon skipping.
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    Chapter 24 Identification of Peptides for Tissue-Specific Delivery
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    Chapter 25 Systemic Delivery of Antisense Oligomer in Animal Models and Its Implications for Treating DMD.
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    Chapter 26 Cell-Penetrating Peptides Enhance Systemic Delivery of Antisense Morpholino Oligomers
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    Chapter 27 Optimizing Tissue-Specific Antisense Oligonucleotide–Peptide Conjugates
Attention for Chapter 13: Antisense-mediated exon skipping to shift alternative splicing to treat cancer.
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Chapter title
Antisense-mediated exon skipping to shift alternative splicing to treat cancer.
Chapter number 13
Book title
Exon Skipping
Published in
Methods in molecular biology, January 2012
DOI 10.1007/978-1-61779-767-5_13
Pubmed ID
22454063
Book ISBNs
978-1-61779-766-8, 978-1-61779-767-5
Authors

Wan, Jing, Jing Wan

Abstract

Manipulation of alternative splicing is a unique way of regulating gene expression. Here, a detailed protocol is presented for modification of HER2 pre-mRNA alternative splicing. A 20-mer splice switching oligonucleotide (SSO) targeting exon 15 in HER2 pre-mRNA induced skipping of exon 15, resulted in significant downregulation of full-length HER2 mRNA and protein expression in HER2-overexpressing breast cancer cell line SK-BR-3.

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Mendeley readers

The data shown below were compiled from readership statistics for 2 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 2 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 2 100%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 1 50%
Computer Science 1 50%

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