28) The largest of these #RCTs, #TREAT, used #darbepoetin to target Hgb of 13 g/dL in the intervention group (vs. 9 g/dL in placebo). It showed that higher Hgb targets were associated with ✅No effect on CV or renal outcomes ⬆️Risk of stroke 👉🏼🔓https://t.c
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TREAT (c. 2009) 4000 CKD patients. 🩸Target Hgb 13 g/dL, achieved 12.5 versus 11 with placebo. 🩸No improved kidney or CV outcomes. 🩸Increased risk of stroke and cancer deaths in treatment group. 🩸Decreased transfusions and modest improvement in QoL. https:/
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@beauregard2 And why not? look up CV for epo. here is Aranesp:Fatal or nonfatal stroke occurred in 101 patients assigned to darbepoetin alfa and 53 patients assigned to placebo (hazard ratio, 1.92; 95% CI, 1.38 to 2.68; P<0.001). https://t.co/8RFHcJts8
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RT @NephJC: T0: Now let’s see what the TREAT Trial showed us: The Darbapoetin group had higher stroke events and higher venous and arterial…