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Mendeley readers
Attention Score in Context
| Title |
Crystal structure of the ZP-N domain of ZP3 reveals the core fold of animal egg coats
|
|---|---|
| Published in |
Nature, December 2008
|
| DOI | 10.1038/nature07599 |
| Pubmed ID | |
| Authors |
Magnus Monné, Ling Han, Thomas Schwend, Sofia Burendahl, Luca Jovine |
| Abstract |
Species-specific recognition between the egg extracellular matrix (zona pellucida) and sperm is the first, crucial step of mammalian fertilization. Zona pellucida filament components ZP3 and ZP2 act as sperm receptors, and mice lacking either of the corresponding genes produce oocytes without a zona pellucida and are completely infertile. Like their counterparts in the vitelline envelope of non-mammalian eggs and many other secreted eukaryotic proteins, zona pellucida subunits polymerize using a 'zona pellucida (ZP) domain' module, whose conserved amino-terminal part (ZP-N) was suggested to constitute a domain of its own. No atomic structure has been reported for ZP domain proteins, and there is no structural information on any conserved vertebrate protein that is essential for fertilization and directly involved in egg-sperm binding. Here we describe the 2.3 ångström (A) resolution structure of the ZP-N fragment of mouse primary sperm receptor ZP3. The ZP-N fold defines a new immunoglobulin superfamily subtype with a beta-sheet extension characterized by an E' strand and an invariant tyrosine residue implicated in polymerization. The structure strongly supports the presence of ZP-N repeats within the N-terminal region of ZP2 and other vertebrate zona pellucida/vitelline envelope proteins, with implications for overall egg coat architecture, the post-fertilization block to polyspermy and speciation. Moreover, it provides an important framework for understanding human diseases caused by mutations in ZP domain proteins and developing new methods of non-hormonal contraception. |
Mendeley readers
The data shown below were compiled from readership statistics for 88 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 1% |
| Australia | 1 | 1% |
| United Kingdom | 1 | 1% |
| Denmark | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 83 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 28 | 32% |
| Student > Ph. D. Student | 22 | 25% |
| Student > Bachelor | 7 | 8% |
| Professor | 6 | 7% |
| Student > Master | 6 | 7% |
| Other | 10 | 11% |
| Unknown | 9 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 42 | 48% |
| Biochemistry, Genetics and Molecular Biology | 17 | 19% |
| Chemistry | 6 | 7% |
| Medicine and Dentistry | 2 | 2% |
| Computer Science | 2 | 2% |
| Other | 7 | 8% |
| Unknown | 12 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2018.
All research outputs
#6,377,613
of 22,660,862 outputs
Outputs from Nature
#62,289
of 90,600 outputs
Outputs of similar age
#40,208
of 165,571 outputs
Outputs of similar age from Nature
#384
of 508 outputs
Altmetric has tracked 22,660,862 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 90,600 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 99.2. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 165,571 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 508 others from the same source and published within six weeks on either side of this one. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.