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Magnetoencephalography Demonstrates Multiple Asynchronous Generators During Human Sleep Spindles

Overview of attention for article published in Journal of Neurophysiology, July 2010
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  • Above-average Attention Score compared to outputs of the same age (63rd percentile)
  • Good Attention Score compared to outputs of the same age and source (79th percentile)

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Citations

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Title
Magnetoencephalography Demonstrates Multiple Asynchronous Generators During Human Sleep Spindles
Published in
Journal of Neurophysiology, July 2010
DOI 10.1152/jn.00198.2010
Pubmed ID
Authors

Nima Dehghani, Sydney S. Cash, Andrea O. Rossetti, Chih Chuan Chen, Eric Halgren

Abstract

Sleep spindles are approximately 1 s bursts of 10-16 Hz activity that occur during stage 2 sleep. Spindles are highly synchronous across the cortex and thalamus in animals, and across the scalp in humans, implying correspondingly widespread and synchronized cortical generators. However, prior studies have noted occasional dissociations of the magnetoencephalogram (MEG) from the EEG during spindles, although detailed studies of this phenomenon have been lacking. We systematically compared high-density MEG and EEG recordings during naturally occurring spindles in healthy humans. As expected, EEG was highly coherent across the scalp, with consistent topography across spindles. In contrast, the simultaneously recorded MEG was not synchronous, but varied strongly in amplitude and phase across locations and spindles. Overall, average coherence between pairs of EEG sensors was approximately 0.7, whereas MEG coherence was approximately 0.3 during spindles. Whereas 2 principle components explained approximately 50% of EEG spindle variance, >15 were required for MEG. Each PCA component for MEG typically involved several widely distributed locations, which were relatively coherent with each other. These results show that, in contrast to current models based on animal experiments, multiple asynchronous neural generators are active during normal human sleep spindles and are visible to MEG. It is possible that these multiple sources may overlap sufficiently in different EEG sensors to appear synchronous. Alternatively, EEG recordings may reflect diffusely distributed synchronous generators that are less visible to MEG. An intriguing possibility is that MEG preferentially records from the focal core thalamocortical system during spindles, and EEG from the distributed matrix system.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 3%
Canada 2 3%
Korea, Republic of 1 1%
France 1 1%
Unknown 62 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 18 26%
Student > Ph. D. Student 14 21%
Professor 7 10%
Other 5 7%
Student > Postgraduate 5 7%
Other 13 19%
Unknown 6 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 23 34%
Neuroscience 13 19%
Medicine and Dentistry 12 18%
Psychology 6 9%
Computer Science 2 3%
Other 3 4%
Unknown 9 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 March 2016.
All research outputs
#3,542,585
of 7,859,726 outputs
Outputs from Journal of Neurophysiology
#1,245
of 3,192 outputs
Outputs of similar age
#88,624
of 249,446 outputs
Outputs of similar age from Journal of Neurophysiology
#36
of 198 outputs
Altmetric has tracked 7,859,726 research outputs across all sources so far. This one has received more attention than most of these and is in the 53rd percentile.
So far Altmetric has tracked 3,192 research outputs from this source. They receive a mean Attention Score of 3.7. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 249,446 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.
We're also able to compare this research output to 198 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.