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MAGE-RING Protein Complexes Comprise a Family of E3 Ubiquitin Ligases

Overview of attention for article published in Molecular Cell, September 2010
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Title
MAGE-RING Protein Complexes Comprise a Family of E3 Ubiquitin Ligases
Published in
Molecular Cell, September 2010
DOI 10.1016/j.molcel.2010.08.029
Pubmed ID
Authors

Jennifer M. Doyle, Jinlan Gao, Jiawei Wang, Maojun Yang, Patrick Ryan Potts

Abstract

The melanoma antigen (MAGE) family consists of more than 60 genes, many of which are cancer-testis antigens that are highly expressed in cancer and play a critical role in tumorigenesis. However, the biochemical and cellular functions of this enigmatic family of proteins have remained elusive. Here, we identify really interesting new gene (RING) domain proteins as binding partners for MAGE family proteins. Multiple MAGE family proteins bind E3 RING ubiquitin ligases with specificity. The crystal structure of one of these MAGE-RING complexes, MAGE-G1-NSE1, reveals structural insights into MAGE family proteins and their interaction with E3 RING ubiquitin ligases. Biochemical and cellular assays demonstrate that MAGE proteins enhance the ubiquitin ligase activity of RING domain proteins. For example, MAGE-C2-TRIM28 is shown to target p53 for degradation in a proteasome-dependent manner, consistent with its tumorigenic functions. These findings define a biochemical and cellular function for the MAGE protein family.

Mendeley readers

The data shown below were compiled from readership statistics for 280 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 <1%
United States 1 <1%
Italy 1 <1%
Canada 1 <1%
Unknown 275 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 72 26%
Researcher 56 20%
Student > Bachelor 38 14%
Student > Master 32 11%
Professor > Associate Professor 15 5%
Other 40 14%
Unknown 27 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 120 43%
Biochemistry, Genetics and Molecular Biology 82 29%
Medicine and Dentistry 22 8%
Chemistry 7 3%
Immunology and Microbiology 7 3%
Other 11 4%
Unknown 31 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 September 2010.
All research outputs
#7,687,864
of 12,304,689 outputs
Outputs from Molecular Cell
#4,103
of 5,184 outputs
Outputs of similar age
#124,381
of 239,042 outputs
Outputs of similar age from Molecular Cell
#46
of 74 outputs
Altmetric has tracked 12,304,689 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,184 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.8. This one is in the 6th percentile – i.e., 6% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 239,042 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 74 others from the same source and published within six weeks on either side of this one. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.