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Attention Score in Context
| Title |
Detailed immunohistochemical characterization of temporal and spatial progression of Alzheimer's disease-related pathologies in male triple-transgenic mice
|
|---|---|
| Published in |
BMC Neuroscience, August 2008
|
| DOI | 10.1186/1471-2202-9-81 |
| Pubmed ID | |
| Authors |
Michael A Mastrangelo, William J Bowers |
| Abstract |
Several transgenic animal models genetically predisposed to develop Alzheimer's disease (AD)-like pathology have been engineered to facilitate the study of disease pathophysiology and the vetting of potential disease-modifying therapeutics. The triple transgenic mouse model of AD (3xTg-AD) harbors three AD-related genetic loci: human PS1M146V, human APPswe, and human tauP301L. These mice develop both amyloid plaques and neurofibrillary tangle-like pathology in a progressive and age-dependent manner, while these pathological hallmarks are predominantly restricted to the hippocampus, amygdala, and the cerebral cortex the main foci of AD neuropathology in humans. This model represents, at present, one of the most advanced preclinical tools available and is being employed ever increasingly in the study of mechanisms underlying AD, yet a detailed regional and temporal assessment of the subtleties of disease-related pathologies has not been reported. |
Mendeley readers
The data shown below were compiled from readership statistics for 207 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 3 | 1% |
| Luxembourg | 2 | <1% |
| United States | 2 | <1% |
| Italy | 1 | <1% |
| Austria | 1 | <1% |
| India | 1 | <1% |
| Germany | 1 | <1% |
| Mexico | 1 | <1% |
| Netherlands | 1 | <1% |
| Other | 2 | <1% |
| Unknown | 192 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 54 | 26% |
| Researcher | 28 | 14% |
| Student > Bachelor | 22 | 11% |
| Student > Master | 20 | 10% |
| Professor | 14 | 7% |
| Other | 34 | 16% |
| Unknown | 35 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 57 | 28% |
| Neuroscience | 47 | 23% |
| Medicine and Dentistry | 16 | 8% |
| Biochemistry, Genetics and Molecular Biology | 11 | 5% |
| Psychology | 9 | 4% |
| Other | 21 | 10% |
| Unknown | 46 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 September 2022.
All research outputs
#15,135,177
of 23,275,636 outputs
Outputs from BMC Neuroscience
#664
of 1,258 outputs
Outputs of similar age
#72,988
of 86,095 outputs
Outputs of similar age from BMC Neuroscience
#9
of 12 outputs
Altmetric has tracked 23,275,636 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,258 research outputs from this source. They receive a mean Attention Score of 4.4. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 86,095 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.