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Lysosomes and oxidative stress in aging and apoptosis.

Overview of attention for article published in Biochimica et Biophysica Acta (BBA), February 2008
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  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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Readers on

mendeley
100 Mendeley
citeulike
2 CiteULike
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Title
Lysosomes and oxidative stress in aging and apoptosis.
Published in
Biochimica et Biophysica Acta (BBA), February 2008
DOI 10.1016/j.bbagen.2008.01.009
Pubmed ID
Authors

Kurz T, Terman A, Gustafsson B, Brunk UT, Tino Kurz, Alexei Terman, Bertil Gustafsson, Ulf T. Brunk

Abstract

The lysosomal compartment consists of numerous acidic vesicles (pH approximately 4-5) that constantly fuse and divide. It receives a large number of hydrolases from the trans-Golgi network, while their substrates arrive from both the cell's outside (heterophagy) and inside (autophagy). Many macromolecules under degradation inside lysosomes contain iron that, when released in labile form, makes lysosomes sensitive to oxidative stress. The magnitude of generated lysosomal destabilization determines if reparative autophagy, apoptosis, or necrosis will follow. Apart from being an essential turnover process, autophagy is also a mechanism for cells to repair inflicted damage, and to survive temporary starvation. The inevitable diffusion of hydrogen peroxide into iron-rich lysosomes causes the slow oxidative formation of lipofuscin in long-lived postmitotic cells, where it finally occupies a substantial part of the volume of the lysosomal compartment. This seems to result in a misdirection of lysosomal enzymes away from autophagosomes, resulting in depressed autophagy and the accumulation of malfunctioning mitochondria and proteins with consequent cellular dysfunction. This scenario might put aging into the category of autophagy disorders.

Mendeley readers

The data shown below were compiled from readership statistics for 100 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 3%
Italy 2 2%
Germany 1 1%
Australia 1 1%
South Africa 1 1%
United Kingdom 1 1%
Brazil 1 1%
Sweden 1 1%
Argentina 1 1%
Other 1 1%
Unknown 87 87%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 28 28%
Researcher 20 20%
Professor > Associate Professor 10 10%
Student > Bachelor 8 8%
Student > Master 7 7%
Other 27 27%
Readers by discipline Count As %
Agricultural and Biological Sciences 51 51%
Medicine and Dentistry 17 17%
Biochemistry, Genetics and Molecular Biology 14 14%
Unspecified 6 6%
Chemistry 5 5%
Other 7 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 April 2008.
All research outputs
#2,018,133
of 3,635,018 outputs
Outputs from Biochimica et Biophysica Acta (BBA)
#2,678
of 3,853 outputs
Outputs of similar age
#99,683
of 231,923 outputs
Outputs of similar age from Biochimica et Biophysica Acta (BBA)
#19
of 57 outputs
Altmetric has tracked 3,635,018 research outputs across all sources so far. This one is in the 26th percentile – i.e., 26% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,853 research outputs from this source. They receive a mean Attention Score of 2.5. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 231,923 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 57 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.