You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Dissecting the molecular architecture of integrin adhesion sites by cryo-electron tomography
|
|---|---|
| Published in |
Nature Cell Biology, August 2010
|
| DOI | 10.1038/ncb2095 |
| Pubmed ID | |
| Authors |
Israel Patla, Tova Volberg, Nadav Elad, Vera Hirschfeld-Warneken, Carsten Grashoff, Reinhard Fässler, Joachim P. Spatz, Benjamin Geiger, Ohad Medalia |
| Abstract |
Focal adhesions are integrin-based multiprotein complexes, several micrometres in diameter, that mechanically link the extracellular matrix with the termini of actin bundles. The molecular diversity of focal adhesions and their role in cell migration and matrix sensing has been extensively studied, but their ultrastructural architecture is still unknown. We present the first three-dimensional structural reconstruction of focal adhesions using cryo-electron tomography. Our analyses reveal that the membrane-cytoskeleton interaction at focal adhesions is mediated through particles located at the cell membrane and attached to actin fibres. The particles have diameters of 25 +/- 5 nm, and an average interspacing of approximately 45 nm. Treatment with the Rho-kinase inhibitor Y-27632 induces a rapid decrease in particle diameter, suggesting that they are highly mechanosensitive. Our findings clarify the internal architecture of focal adhesions at molecular resolution, and provide insights into their scaffolding and mechanosensory functions. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 358 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 12 | 3% |
| United Kingdom | 7 | 2% |
| Germany | 4 | 1% |
| France | 3 | <1% |
| Switzerland | 2 | <1% |
| India | 2 | <1% |
| Israel | 2 | <1% |
| Portugal | 1 | <1% |
| Iceland | 1 | <1% |
| Other | 4 | 1% |
| Unknown | 320 | 89% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 99 | 28% |
| Researcher | 96 | 27% |
| Student > Master | 25 | 7% |
| Professor | 24 | 7% |
| Student > Bachelor | 20 | 6% |
| Other | 57 | 16% |
| Unknown | 37 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 155 | 43% |
| Biochemistry, Genetics and Molecular Biology | 59 | 16% |
| Engineering | 24 | 7% |
| Chemistry | 18 | 5% |
| Physics and Astronomy | 16 | 4% |
| Other | 39 | 11% |
| Unknown | 47 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 December 2023.
All research outputs
#6,606,902
of 24,965,047 outputs
Outputs from Nature Cell Biology
#2,339
of 4,060 outputs
Outputs of similar age
#30,499
of 100,657 outputs
Outputs of similar age from Nature Cell Biology
#17
of 32 outputs
Altmetric has tracked 24,965,047 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 4,060 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 23.0. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 100,657 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.