Title |
Blood autoantibody and cytokine profiles predict response to anti-tumor necrosis factor therapy in rheumatoid arthritis
|
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Published in |
Arthritis Research & Therapy, May 2009
|
DOI | 10.1186/ar2706 |
Pubmed ID | |
Authors |
Wolfgang Hueber, Beren H Tomooka, Franak Batliwalla, Wentian Li, Paul A Monach, Robert J Tibshirani, Ronald F Van Vollenhoven, Jon Lampa, Kazuyoshi Saito, Yoshiya Tanaka, Mark C Genovese, Lars Klareskog, Peter K Gregersen, William H Robinson |
Abstract |
Anti-TNF therapies have revolutionized the treatment of rheumatoid arthritis (RA), a common systemic autoimmune disease involving destruction of the synovial joints. However, in the practice of rheumatology approximately one-third of patients demonstrate no clinical improvement in response to treatment with anti-TNF therapies, while another third demonstrate a partial response, and one-third an excellent and sustained response. Since no clinical or laboratory tests are available to predict response to anti-TNF therapies, great need exists for predictive biomarkers. |
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Geographical breakdown
Country | Count | As % |
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United Kingdom | 3 | 2% |
Colombia | 1 | <1% |
Germany | 1 | <1% |
China | 1 | <1% |
Russia | 1 | <1% |
United States | 1 | <1% |
Philippines | 1 | <1% |
Unknown | 118 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 35 | 28% |
Student > Ph. D. Student | 22 | 17% |
Student > Bachelor | 10 | 8% |
Student > Postgraduate | 10 | 8% |
Professor > Associate Professor | 10 | 8% |
Other | 26 | 20% |
Unknown | 14 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 41 | 32% |
Agricultural and Biological Sciences | 39 | 31% |
Biochemistry, Genetics and Molecular Biology | 14 | 11% |
Immunology and Microbiology | 10 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
Other | 4 | 3% |
Unknown | 17 | 13% |