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Nanosized hydroxyapatite and other calcium phosphates: Chemistry of formation and application as drug and gene delivery agents

Overview of attention for article published in Journal of Biomedical Materials Research, Part B: Applied Biomaterials, November 2010
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

patent
2 patents
f1000
1 research highlight platform

Citations

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369 Dimensions

Readers on

mendeley
318 Mendeley
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Title
Nanosized hydroxyapatite and other calcium phosphates: Chemistry of formation and application as drug and gene delivery agents
Published in
Journal of Biomedical Materials Research, Part B: Applied Biomaterials, November 2010
DOI 10.1002/jbm.b.31746
Pubmed ID
Authors

Vuk Uskoković, Dragan P. Uskoković

Abstract

The first part of this review looks at the fundamental properties of hydroxyapatite (HAP), the basic mineral constituent of mammalian hard tissues, including the physicochemical features that govern its formation by precipitation. A special emphasis is placed on the analysis of qualities of different methods of synthesis and of the phase transformations intrinsic to the formation of HAP following precipitation from aqueous solutions. This serves as an introduction to the second part and the main subject of this review, which relates to the discourse regarding the prospects of fabrication of ultrafine, nanosized particles based on calcium phosphate carriers with various therapeutic and/or diagnostic agents coated on and/or encapsulated within the particles. It is said that the particles could be either surface-functionalized with amphiphiles, peptides, proteins, or nucleic acids or injected with therapeutic agents, magnetic ions, or fluorescent molecules. Depending on the additive, they could be subsequently used for a variety of applications, including the controlled delivery and release of therapeutic agents (extracellularly or intracellularly), magnetic resonance imaging and hyperthermia therapy, cell separation, blood detoxification, peptide or oligonucleotide chromatography and ultrasensitive detection of biomolecules, and in vivo and in vitro gene transfection. Calcium phosphate nanoparticles as carriers of therapeutic agents that would enable a controlled drug release to treat a given bone infection and at the same be resorbed in the body so as to regenerate hard tissue lost to disease are emphasized hereby as one of the potentially attractive smart materials for the modern medicine.

Mendeley readers

The data shown below were compiled from readership statistics for 318 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Bangladesh 1 <1%
France 1 <1%
Ireland 1 <1%
Italy 1 <1%
Latvia 1 <1%
Sweden 1 <1%
Canada 1 <1%
Argentina 1 <1%
Japan 1 <1%
Other 1 <1%
Unknown 308 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 69 22%
Student > Master 56 18%
Researcher 47 15%
Student > Bachelor 36 11%
Student > Doctoral Student 24 8%
Other 41 13%
Unknown 45 14%
Readers by discipline Count As %
Materials Science 66 21%
Chemistry 58 18%
Engineering 35 11%
Agricultural and Biological Sciences 26 8%
Medicine and Dentistry 20 6%
Other 47 15%
Unknown 66 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 May 2020.
All research outputs
#3,191,890
of 17,749,513 outputs
Outputs from Journal of Biomedical Materials Research, Part B: Applied Biomaterials
#66
of 1,023 outputs
Outputs of similar age
#35,491
of 226,361 outputs
Outputs of similar age from Journal of Biomedical Materials Research, Part B: Applied Biomaterials
#2
of 18 outputs
Altmetric has tracked 17,749,513 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,023 research outputs from this source. They receive a mean Attention Score of 3.3. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 226,361 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.